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Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function

Growth differentiation factor 11 (GDF-11) has been implicated in reverse effects of ageing on the central nervous system of humans. β2-microglobulin (β2-MG) has been reported to negatively regulate cognition. However, there is a lot of controversy about the role of GDF-11 and β2-MG in ageing and cog...

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Autores principales: Yang, Rungong, Fu, Shuhong, Zhao, Liang, Zhen, Bei, Ye, Ling, Niu, Xiaolu, Li, Xiaoxia, Zhang, Pumin, Bai, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869852/
https://www.ncbi.nlm.nih.gov/pubmed/28611236
http://dx.doi.org/10.1042/CS20171028
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author Yang, Rungong
Fu, Shuhong
Zhao, Liang
Zhen, Bei
Ye, Ling
Niu, Xiaolu
Li, Xiaoxia
Zhang, Pumin
Bai, Jie
author_facet Yang, Rungong
Fu, Shuhong
Zhao, Liang
Zhen, Bei
Ye, Ling
Niu, Xiaolu
Li, Xiaoxia
Zhang, Pumin
Bai, Jie
author_sort Yang, Rungong
collection PubMed
description Growth differentiation factor 11 (GDF-11) has been implicated in reverse effects of ageing on the central nervous system of humans. β2-microglobulin (β2-MG) has been reported to negatively regulate cognition. However, there is a lot of controversy about the role of GDF-11 and β2-MG in ageing and cognitive regulation. To examine the involvement of GDF-11 and β2-MG in the ageing process and cognitive dysfunction, a total of 51 healthy subjects and 41 elderly patients with different degrees of age-related cognitive impairment participated in the study. We measured plasma GDF-11 and β2-MG levels using ELISA and immunoturbidimetry, respectively. The results were statistically analyzed to evaluate the associations between levels of GDF-11 and β2-MG, and ageing and cognitive impairments. Circulating GDF-11 levels did not decline with age or correlate with ageing in healthy Chinese males. We did not detect differences in circulating GDF-11 levels amongst the healthy advanced age and four cognitive impairment groups. β2-MG levels increased with age, but there was no significant difference between healthy elderly males and advanced age males. Increased levels of β2-MG were observed in the dementia group compared with the healthy advanced age group. Our results suggest that circulating GDF-11 may not exert a protective effect during the ageing process or on cognitive function, and β2-MG may play a role in ageing and cognitive impairment. However, it is possible that the relatively small sample size in the present study affected the quality of the statistical analysis, and future studies are needed to further validate our findings.
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spelling pubmed-58698522018-04-05 Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function Yang, Rungong Fu, Shuhong Zhao, Liang Zhen, Bei Ye, Ling Niu, Xiaolu Li, Xiaoxia Zhang, Pumin Bai, Jie Clin Sci (Lond) Research Articles Growth differentiation factor 11 (GDF-11) has been implicated in reverse effects of ageing on the central nervous system of humans. β2-microglobulin (β2-MG) has been reported to negatively regulate cognition. However, there is a lot of controversy about the role of GDF-11 and β2-MG in ageing and cognitive regulation. To examine the involvement of GDF-11 and β2-MG in the ageing process and cognitive dysfunction, a total of 51 healthy subjects and 41 elderly patients with different degrees of age-related cognitive impairment participated in the study. We measured plasma GDF-11 and β2-MG levels using ELISA and immunoturbidimetry, respectively. The results were statistically analyzed to evaluate the associations between levels of GDF-11 and β2-MG, and ageing and cognitive impairments. Circulating GDF-11 levels did not decline with age or correlate with ageing in healthy Chinese males. We did not detect differences in circulating GDF-11 levels amongst the healthy advanced age and four cognitive impairment groups. β2-MG levels increased with age, but there was no significant difference between healthy elderly males and advanced age males. Increased levels of β2-MG were observed in the dementia group compared with the healthy advanced age group. Our results suggest that circulating GDF-11 may not exert a protective effect during the ageing process or on cognitive function, and β2-MG may play a role in ageing and cognitive impairment. However, it is possible that the relatively small sample size in the present study affected the quality of the statistical analysis, and future studies are needed to further validate our findings. Portland Press Ltd. 2017-07-07 /pmc/articles/PMC5869852/ /pubmed/28611236 http://dx.doi.org/10.1042/CS20171028 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Yang, Rungong
Fu, Shuhong
Zhao, Liang
Zhen, Bei
Ye, Ling
Niu, Xiaolu
Li, Xiaoxia
Zhang, Pumin
Bai, Jie
Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title_full Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title_fullStr Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title_full_unstemmed Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title_short Quantitation of circulating GDF-11 and β2-MG in aged patients with age-related impairment in cognitive function
title_sort quantitation of circulating gdf-11 and β2-mg in aged patients with age-related impairment in cognitive function
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869852/
https://www.ncbi.nlm.nih.gov/pubmed/28611236
http://dx.doi.org/10.1042/CS20171028
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