Systems modelling ageing: from single senescent cells to simple multi-cellular models

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of b...

Descripción completa

Detalles Bibliográficos
Autores principales: Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869859/
https://www.ncbi.nlm.nih.gov/pubmed/28698310
http://dx.doi.org/10.1042/EBC20160087
Descripción
Sumario:Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.

Ejemplares similares