Systems modelling ageing: from single senescent cells to simple multi-cellular models

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of b...

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Autores principales: Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869859/
https://www.ncbi.nlm.nih.gov/pubmed/28698310
http://dx.doi.org/10.1042/EBC20160087
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author Martinez Guimera, Alvaro
Welsh, Ciaran
Dalle Pezze, Piero
Fullard, Nicola
Nelson, Glyn
Roger, Mathilde F.
Przyborski, Stefan A.
Shanley, Daryl P.
author_facet Martinez Guimera, Alvaro
Welsh, Ciaran
Dalle Pezze, Piero
Fullard, Nicola
Nelson, Glyn
Roger, Mathilde F.
Przyborski, Stefan A.
Shanley, Daryl P.
author_sort Martinez Guimera, Alvaro
collection PubMed
description Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context.
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spelling pubmed-58698592018-04-05 Systems modelling ageing: from single senescent cells to simple multi-cellular models Martinez Guimera, Alvaro Welsh, Ciaran Dalle Pezze, Piero Fullard, Nicola Nelson, Glyn Roger, Mathilde F. Przyborski, Stefan A. Shanley, Daryl P. Essays Biochem Review Articles Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we discuss these issues and work through the process of building an integrated model for cellular senescence as a single cell and in a simple tissue context. Portland Press Ltd. 2017-07-11 /pmc/articles/PMC5869859/ /pubmed/28698310 http://dx.doi.org/10.1042/EBC20160087 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Martinez Guimera, Alvaro
Welsh, Ciaran
Dalle Pezze, Piero
Fullard, Nicola
Nelson, Glyn
Roger, Mathilde F.
Przyborski, Stefan A.
Shanley, Daryl P.
Systems modelling ageing: from single senescent cells to simple multi-cellular models
title Systems modelling ageing: from single senescent cells to simple multi-cellular models
title_full Systems modelling ageing: from single senescent cells to simple multi-cellular models
title_fullStr Systems modelling ageing: from single senescent cells to simple multi-cellular models
title_full_unstemmed Systems modelling ageing: from single senescent cells to simple multi-cellular models
title_short Systems modelling ageing: from single senescent cells to simple multi-cellular models
title_sort systems modelling ageing: from single senescent cells to simple multi-cellular models
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869859/
https://www.ncbi.nlm.nih.gov/pubmed/28698310
http://dx.doi.org/10.1042/EBC20160087
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