Cargando…

Host–pathogen interactions and subversion of autophagy

Macroautophagy (‘autophagy’), is the process by which cells can form a double-membraned vesicle that encapsulates material to be degraded by the lysosome. This can include complex structures such as damaged mitochondria, peroxisomes, protein aggregates and large swathes of cytoplasm that can not be...

Descripción completa

Detalles Bibliográficos
Autor principal: McEwan, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869863/
https://www.ncbi.nlm.nih.gov/pubmed/29233878
http://dx.doi.org/10.1042/EBC20170058
_version_ 1783309355351801856
author McEwan, David G.
author_facet McEwan, David G.
author_sort McEwan, David G.
collection PubMed
description Macroautophagy (‘autophagy’), is the process by which cells can form a double-membraned vesicle that encapsulates material to be degraded by the lysosome. This can include complex structures such as damaged mitochondria, peroxisomes, protein aggregates and large swathes of cytoplasm that can not be processed efficiently by other means of degradation. Recycling of amino acids and lipids through autophagy allows the cell to form intracellular pools that aid survival during periods of stress, including growth factor deprivation, amino acid starvation or a depleted oxygen supply. One of the major functions of autophagy that has emerged over the last decade is its importance as a safeguard against infection. The ability of autophagy to selectively target intracellular pathogens for destruction is now regarded as a key aspect of the innate immune response. However, pathogens have evolved mechanisms to either evade or reconfigure the autophagy pathway for their own survival. Understanding how pathogens interact with and manipulate the host autophagy pathway will hopefully provide a basis for combating infection and increase our understanding of the role and regulation of autophagy. Herein, we will discuss how the host cell can identify and target invading pathogens and how pathogens have adapted in order to evade destruction by the host cell. In particular, we will focus on interactions between the mammalian autophagy gene 8 (ATG8) proteins and the host and pathogen effector proteins.
format Online
Article
Text
id pubmed-5869863
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-58698632018-04-05 Host–pathogen interactions and subversion of autophagy McEwan, David G. Essays Biochem Review Articles Macroautophagy (‘autophagy’), is the process by which cells can form a double-membraned vesicle that encapsulates material to be degraded by the lysosome. This can include complex structures such as damaged mitochondria, peroxisomes, protein aggregates and large swathes of cytoplasm that can not be processed efficiently by other means of degradation. Recycling of amino acids and lipids through autophagy allows the cell to form intracellular pools that aid survival during periods of stress, including growth factor deprivation, amino acid starvation or a depleted oxygen supply. One of the major functions of autophagy that has emerged over the last decade is its importance as a safeguard against infection. The ability of autophagy to selectively target intracellular pathogens for destruction is now regarded as a key aspect of the innate immune response. However, pathogens have evolved mechanisms to either evade or reconfigure the autophagy pathway for their own survival. Understanding how pathogens interact with and manipulate the host autophagy pathway will hopefully provide a basis for combating infection and increase our understanding of the role and regulation of autophagy. Herein, we will discuss how the host cell can identify and target invading pathogens and how pathogens have adapted in order to evade destruction by the host cell. In particular, we will focus on interactions between the mammalian autophagy gene 8 (ATG8) proteins and the host and pathogen effector proteins. Portland Press Ltd. 2017-12-12 /pmc/articles/PMC5869863/ /pubmed/29233878 http://dx.doi.org/10.1042/EBC20170058 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
McEwan, David G.
Host–pathogen interactions and subversion of autophagy
title Host–pathogen interactions and subversion of autophagy
title_full Host–pathogen interactions and subversion of autophagy
title_fullStr Host–pathogen interactions and subversion of autophagy
title_full_unstemmed Host–pathogen interactions and subversion of autophagy
title_short Host–pathogen interactions and subversion of autophagy
title_sort host–pathogen interactions and subversion of autophagy
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869863/
https://www.ncbi.nlm.nih.gov/pubmed/29233878
http://dx.doi.org/10.1042/EBC20170058
work_keys_str_mv AT mcewandavidg hostpathogeninteractionsandsubversionofautophagy