(1)H, (13)C, (15)N resonance assignment of human YAP 50–171 fragment

Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy....

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Detalles Bibliográficos
Autores principales: Feichtinger, Michael, Sára, Tomáš, Platzer, Gerald, Mateos, Borja, Bokhovchuk, Fedir, Chène, Patrick, Konrat, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869869/
https://www.ncbi.nlm.nih.gov/pubmed/29372459
http://dx.doi.org/10.1007/s12104-018-9805-8
Descripción
Sumario:Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy. The TEAD binding domain of YAP was mapped to protein residues 50–171. To obtain further structural insights into this 12 kDa segment of YAP, we report a backbone and a partial sidechain assignment of recombinant YAP 50–171.

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