Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice

In the adult mammalian hippocampus, new neurons are constantly added to the dentate gyrus. Adult neurogenesis is impaired in several neurodegenerative mouse models including α-synuclein (a-syn) transgenic mice. Among different a-syn species, a-syn oligomers were reported to be the most toxic species...

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Detalles Bibliográficos
Autores principales: Regensburger, Martin, Schreglmann, Sebastian R., Stoll, Svenja, Rockenstein, Edward, Loskarn, Sandra, Xiang, Wei, Masliah, Eliezer, Winner, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869938/
https://www.ncbi.nlm.nih.gov/pubmed/29124353
http://dx.doi.org/10.1007/s00429-017-1561-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869938/
https://www.ncbi.nlm.nih.gov/pubmed/29124353
http://dx.doi.org/10.1007/s00429-017-1561-5

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