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Htt(Q111/+) Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction

BACKGROUND: Successful disease-modifying therapy for Huntington’s disease (HD) will require therapeutic intervention early in the pathogenic process. Achieving this goal requires identifying phenotypes that are proximal to the HTT CAG repeat expansion. OBJECTIVE: To use Htt CAG knock-in mice, precis...

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Detalles Bibliográficos
Autores principales:	Kovalenko, Marina, Milnerwood, Austen, Giordano, James, St. Claire, Jason, Guide, Jolene R., Stromberg, Mary, Gillis, Tammy, Sapp, Ellen, DiFiglia, Marian, MacDonald, Marcy E., Carroll, Jeffrey B., Lee, Jong-Min, Tappan, Susan, Raymond, Lynn, Wheeler, Vanessa C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Research Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869998/ https://www.ncbi.nlm.nih.gov/pubmed/29480209 http://dx.doi.org/10.3233/JHD-170282

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