Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin

 Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerati...

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Detalles Bibliográficos
Autores principales: Borroni, Barbara, Benussi, Alberto, Premi, Enrico, Alberici, Antonella, Marcello, Elena, Gardoni, Fabrizio, Di Luca, Monica, Padovani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870000/
https://www.ncbi.nlm.nih.gov/pubmed/29171998
http://dx.doi.org/10.3233/JAD-170584
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author Borroni, Barbara
Benussi, Alberto
Premi, Enrico
Alberici, Antonella
Marcello, Elena
Gardoni, Fabrizio
Di Luca, Monica
Padovani, Alessandro
author_facet Borroni, Barbara
Benussi, Alberto
Premi, Enrico
Alberici, Antonella
Marcello, Elena
Gardoni, Fabrizio
Di Luca, Monica
Padovani, Alessandro
author_sort Borroni, Barbara
collection PubMed
description  Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerative dementias. In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers.
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spelling pubmed-58700002018-03-29 Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin Borroni, Barbara Benussi, Alberto Premi, Enrico Alberici, Antonella Marcello, Elena Gardoni, Fabrizio Di Luca, Monica Padovani, Alessandro J Alzheimers Dis Review  Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerative dementias. In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers. IOS Press 2018-03-13 /pmc/articles/PMC5870000/ /pubmed/29171998 http://dx.doi.org/10.3233/JAD-170584 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Borroni, Barbara
Benussi, Alberto
Premi, Enrico
Alberici, Antonella
Marcello, Elena
Gardoni, Fabrizio
Di Luca, Monica
Padovani, Alessandro
Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title_full Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title_fullStr Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title_full_unstemmed Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title_short Biological, Neuroimaging, and Neurophysiological Markers in Frontotemporal Dementia: Three Faces of the Same Coin
title_sort biological, neuroimaging, and neurophysiological markers in frontotemporal dementia: three faces of the same coin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870000/
https://www.ncbi.nlm.nih.gov/pubmed/29171998
http://dx.doi.org/10.3233/JAD-170584
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