Modeling Prion-Like Processing of Tau Protein in Alzheimer’s Disease for Pharmaceutical Development

Following our discovery of a fragment from the repeat domain of tau protein as a structural constituent of the PHF-core in Alzheimer’s disease (AD), we developed an assay that captured several key features of the aggregation process. Tau-tau binding through the core tau fragment could be blocked by...

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Detalles Bibliográficos
Autores principales: Wischik, Claude M., Schelter, Björn O., Wischik, Damon J., Storey, John M. D., Harrington, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870021/
https://www.ncbi.nlm.nih.gov/pubmed/29226873
http://dx.doi.org/10.3233/JAD-170727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870021/
https://www.ncbi.nlm.nih.gov/pubmed/29226873
http://dx.doi.org/10.3233/JAD-170727

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