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Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

Palmitoylethanolamide (PEA) is a pleiotropic lipid mediator with established anti-inflammatory and anti-hyperalgesic activity. Ultramicronized PEA (PEA-um) has superior oral efficacy compared to naïve (non-micronized) PEA. The aim of the present study was two-fold: (1) to evaluate whether oral PEA-u...

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Detalles Bibliográficos
Autores principales:	Petrosino, Stefania, Cordaro, Marika, Verde, Roberta, Schiano Moriello, Aniello, Marcolongo, Gabriele, Schievano, Carlo, Siracusa, Rosalba, Piscitelli, Fabiana, Peritore, Alessio F., Crupi, Rosalia, Impellizzeri, Daniela, Esposito, Emanuela, Cuzzocrea, Salvatore, Di Marzo, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870042/ https://www.ncbi.nlm.nih.gov/pubmed/29615912 http://dx.doi.org/10.3389/fphar.2018.00249

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