Cargando…

Genetic Heterogeneity of Alzheimer’s Disease: Embracing Research Partnerships

Studies on the genetics of Alzheimer’s disease (AD) have revealed the complexity and heterogeneity of the disease. All our studies have supported this evidence and contribute to the current understanding of the genetic architecture of AD. This report reviews the success of our investigations, focusi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nacmias, Benedetta, Bagnoli, Silvia, Piaceri, Irene, Sorbi, Sandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870047/ https://www.ncbi.nlm.nih.gov/pubmed/29103034 http://dx.doi.org/10.3233/JAD-170570

Ejemplares similares

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late-Onset Alzheimer's Disease
por: Tedde, Andrea, et al.
Publicado: (2011)

Influence of ApoE Genotype and Clock T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer’s Disease in Subjective Cognitive Decline and Mild Cognitive Impairment Patients
por: Bessi, Valentina, et al.
Publicado: (2020)

The Huntington’s Disease Gene in an Italian Cohort of Patients with Bipolar Disorder
por: Ferrari, Camilla, et al.
Publicado: (2023)

A Pilot Study Evaluating the Contribution of SLC19A1 (RFC-1) 80G>A Polymorphism to Alzheimer's Disease in Italian Caucasians
por: Coppedè, Fabio, et al.
Publicado: (2014)

Plasma neurofilament light chain as a biomarker of Alzheimer’s disease in Subjective Cognitive Decline and Mild Cognitive Impairment
por: Giacomucci, Giulia, et al.
Publicado: (2022)

Matching Clinical Diagnosis and Amyloid Biomarkers in Alzheimer’s Disease and Frontotemporal Dementia
por: Giacomucci, Giulia, et al.
Publicado: (2021)

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference
por: Sierant, Malgorzata, et al.
Publicado: (2011)

Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis
por: Pomeshchik, Yuriy, et al.
Publicado: (2023)

Differences and Similarities in Empathy Deficit and Its Neural Basis between Logopenic and Amnesic Alzheimer’s Disease
por: Giacomucci, Giulia, et al.
Publicado: (2023)

The Effect of CAG Repeats within the Non-Pathological Range in the HTT Gene on Cognitive Functions in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment
por: Bessi, Valentina, et al.
Publicado: (2021)

Gender differences in cognitive reserve: implication for subjective cognitive decline in women
por: Giacomucci, Giulia, et al.
Publicado: (2021)

Neurofilament Light Chain and Intermediate HTT Alleles as Combined Biomarkers in Italian ALS Patients
por: Ingannato, Assunta, et al.
Publicado: (2021)

Creutzfeldt-Jakob Disease in a Patient with Previous COVID-19 Infection: “The Virus Caused the Derangement in My Brain”
por: Leccese, Deborah, et al.
Publicado: (2023)

Alzheimer’s Disease CSF Biomarker Profiles in Idiopathic Normal Pressure Hydrocephalus
por: Mazzeo, Salvatore, et al.
Publicado: (2022)

Embracing the heterogeneity of natural viruses in mouse studies
por: Fiege, Jessica K., et al.
Publicado: (2022)

Fat mass and obesity-associated gene (FTO) is associated to eating disorders susceptibility and moderates the expression of psychopathological traits
por: Castellini, Giovanni, et al.
Publicado: (2017)

Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment
por: Mazzeo, Salvatore, et al.
Publicado: (2021)

Degradation of EEG microstates patterns in subjective cognitive decline and mild cognitive impairment: Early biomarkers along the Alzheimer’s Disease continuum?
por: Lassi, Michael, et al.
Publicado: (2023)

Early Clinical and Molecular Detection of Alzheimer's Disease
por: Nacmias, Benedetta, et al.
Publicado: (2011)

PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer’s Disease With machine learning: the PREVIEW study protocol
por: Mazzeo, Salvatore, et al.
Publicado: (2023)

Embracing polygenicity: a review of methods and tools for psychiatric genetics research
por: Maier, R. M., et al.
Publicado: (2018)

Emotional dysregulation, alexithymia and neuroticism: a systematic review on the genetic basis of a subset of psychological traits
por: Castellini, Giovanni, et al.
Publicado: (2023)

The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Can Protect Against Cognitive Impairment in Multiple Sclerosis
por: Portaccio, Emilio, et al.
Publicado: (2021)

CAG Repeats Within the Non-pathological Range in the HTT Gene Influence Personality Traits in Patients With Subjective Cognitive Decline: A 13-Year Follow-Up Study
por: Moschini, Valentina, et al.
Publicado: (2022)

Embracing the local: enriching scientific research, education, and outreach on the Texas-Mexico border through a participatory action research partnership.
por: May, Marlynn L, et al.
Publicado: (2003)

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
por: Pomeshchik, Yuriy, et al.
Publicado: (2020)

Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies
por: Pomeshchik, Yuriy, et al.
Publicado: (2021)

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies
por: Pomeshchik, Yuriy, et al.
Publicado: (2023)

Avoid or Embrace? Practice Effects in Alzheimer’s Disease Prevention Trials
por: Aschenbrenner, Andrew J., et al.
Publicado: (2022)

Practice-changing developments in neuro-oncology: embracing heterogeneity
por: Platten, Michael
Publicado: (2019)

Embracing heterogeneity: coalescing the Tree of Life and the future of phylogenomics
por: Bravo, Gustavo A., et al.
Publicado: (2019)

TIME TO EMBRACE HETEROGENEITY IN INTERVENTIONAL STUDIES OF OLDER ADULTS
por: Xue, Qian-Li
Publicado: (2022)

PRESIDENTIAL SYMPOSIUM: BUILDING AND LEVERAGING COMMUNITY PARTNERSHIPS THAT EMBRACE DIVERSITY, ENRICH DISCOVERY, AND REIMAGINE AGING
por: Johnson, Kalisha Bonds, et al.
Publicado: (2022)

BMC Ecology embraces biodiversity research
por: Zauner, Hans
Publicado: (2010)

The visual vernacular: embracing photographs in research
por: Cleland, Jennifer, et al.
Publicado: (2021)

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity
por: Scicluna, Brendon P., et al.
Publicado: (2019)

Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts
por: Guarnieri, Giulia, et al.
Publicado: (2020)

Embracing Complexity: Yeast Evolution Experiments Featuring Standing Genetic Variation
por: Burke, Molly K.
Publicado: (2023)

Proteomes Are of Proteoforms: Embracing the Complexity
por: Carbonara, Katrina, et al.
Publicado: (2021)

Reproducible preclinical research—Is embracing variability the answer?
por: Karp, Natasha A.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ces9t17vo8ibdtofclaa5bgh6m