Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1(−/−)), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blo...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Lucia, Muturi, Harrison T., Ghadieh, Hilda E., Wisniewski, Alexander M., Morgan, Eric E., Quadri, Syed S., Landesberg, Gavin P., Siragy, Helmy M., Vazquez, Guillermo, Scalia, Rosario, Gupta, Rajesh, Najjar, Sonia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870095/
https://www.ncbi.nlm.nih.gov/pubmed/29396368
http://dx.doi.org/10.1016/j.molmet.2018.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870095/
https://www.ncbi.nlm.nih.gov/pubmed/29396368
http://dx.doi.org/10.1016/j.molmet.2018.01.009

Ejemplares similares