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Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

OBJECTIVE: A decline in mitochondrial function and biogenesis as well as increased reactive oxygen species (ROS) are important determinants of aging. With advancing age, there is a concomitant reduction in circulating levels of insulin-like growth factor-1 (IGF-1) that is closely associated with neu...

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Detalles Bibliográficos
Autores principales:	Logan, Sreemathi, Pharaoh, Gavin A., Marlin, M. Caleb, Masser, Dustin R., Matsuzaki, Satoshi, Wronowski, Benjamin, Yeganeh, Alexander, Parks, Eileen E., Premkumar, Pavithra, Farley, Julie A., Owen, Daniel B., Humphries, Kenneth M., Kinter, Michael, Freeman, Willard M., Szweda, Luke I., Van Remmen, Holly, Sonntag, William E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870102/ https://www.ncbi.nlm.nih.gov/pubmed/29398615 http://dx.doi.org/10.1016/j.molmet.2018.01.013

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