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Genome-wide analysis of PDX1 target genes in human pancreatic progenitors

OBJECTIVE: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical mod...

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Detalles Bibliográficos
Autores principales:	Wang, Xianming, Sterr, Michael, Burtscher, Ingo, Chen, Shen, Hieronimus, Anja, Machicao, Fausto, Staiger, Harald, Häring, Hans-Ulrich, Lederer, Gabriele, Meitinger, Thomas, Cernilogar, Filippo M., Schotta, Gunnar, Irmler, Martin, Beckers, Johannes, Hrabě de Angelis, Martin, Ray, Michael, Wright, Christopher V.E., Bakhti, Mostafa, Lickert, Heiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870105/ https://www.ncbi.nlm.nih.gov/pubmed/29396371 http://dx.doi.org/10.1016/j.molmet.2018.01.011

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