TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion

OBJECTIVE: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K(+) (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells remains unknown. We previously determined that in β...

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Detalles Bibliográficos
Autores principales: Vierra, Nicholas C., Dickerson, Matthew T., Jordan, Kelli L., Dadi, Prasanna K., Kadare, Ketaki A., Altman, Molly K., Milian, Sarah C., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870147/
https://www.ncbi.nlm.nih.gov/pubmed/29402588
http://dx.doi.org/10.1016/j.molmet.2018.01.016

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