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Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins

A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. Th...

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Detalles Bibliográficos
Autores principales: Vroemans, Robby, Bamba, Fante, Winters, Jonas, Thomas, Joice, Jacobs, Jeroen, Van Meervelt, Luc, John, Jubi, Dehaen, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870159/
https://www.ncbi.nlm.nih.gov/pubmed/29623124
http://dx.doi.org/10.3762/bjoc.14.49

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