A method combining a random forest-based technique with the modeling of linkage disequilibrium through latent variables, to run multilocus genome-wide association studies

BACKGROUND: Genome-wide association studies (GWASs) have been widely used to discover the genetic basis of complex phenotypes. However, standard single-SNP GWASs suffer from lack of power. In particular, they do not directly account for linkage disequilibrium, that is the dependences between SNPs (S...

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Detalles Bibliográficos
Autor principal: Sinoquet, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870262/
https://www.ncbi.nlm.nih.gov/pubmed/29587628
http://dx.doi.org/10.1186/s12859-018-2054-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870262/
https://www.ncbi.nlm.nih.gov/pubmed/29587628
http://dx.doi.org/10.1186/s12859-018-2054-0

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