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Idiopathic nephrotic syndrome in South African children
BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Makerere Medical School
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870266/ https://www.ncbi.nlm.nih.gov/pubmed/29937885 http://dx.doi.org/10.4314/ahs.v17i4.22 |
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author | Bakhiet, Yassir Mahgoub Mudi, Abdullahi Khumalo, Tholang Moonsamy, Glenda Levy, Cecil |
author_facet | Bakhiet, Yassir Mahgoub Mudi, Abdullahi Khumalo, Tholang Moonsamy, Glenda Levy, Cecil |
author_sort | Bakhiet, Yassir Mahgoub |
collection | PubMed |
description | BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS. METHOD: Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed. RESULTS: Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2–6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%). CONCLUSION: There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports. |
format | Online Article Text |
id | pubmed-5870266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Makerere Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-58702662018-06-22 Idiopathic nephrotic syndrome in South African children Bakhiet, Yassir Mahgoub Mudi, Abdullahi Khumalo, Tholang Moonsamy, Glenda Levy, Cecil Afr Health Sci Articles BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS. METHOD: Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed. RESULTS: Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2–6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%). CONCLUSION: There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports. Makerere Medical School 2017-12 /pmc/articles/PMC5870266/ /pubmed/29937885 http://dx.doi.org/10.4314/ahs.v17i4.22 Text en © 2017 Bakhiet et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Bakhiet, Yassir Mahgoub Mudi, Abdullahi Khumalo, Tholang Moonsamy, Glenda Levy, Cecil Idiopathic nephrotic syndrome in South African children |
title | Idiopathic nephrotic syndrome in South African children |
title_full | Idiopathic nephrotic syndrome in South African children |
title_fullStr | Idiopathic nephrotic syndrome in South African children |
title_full_unstemmed | Idiopathic nephrotic syndrome in South African children |
title_short | Idiopathic nephrotic syndrome in South African children |
title_sort | idiopathic nephrotic syndrome in south african children |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870266/ https://www.ncbi.nlm.nih.gov/pubmed/29937885 http://dx.doi.org/10.4314/ahs.v17i4.22 |
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