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Idiopathic nephrotic syndrome in South African children

BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children...

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Autores principales: Bakhiet, Yassir Mahgoub, Mudi, Abdullahi, Khumalo, Tholang, Moonsamy, Glenda, Levy, Cecil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870266/
https://www.ncbi.nlm.nih.gov/pubmed/29937885
http://dx.doi.org/10.4314/ahs.v17i4.22
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author Bakhiet, Yassir Mahgoub
Mudi, Abdullahi
Khumalo, Tholang
Moonsamy, Glenda
Levy, Cecil
author_facet Bakhiet, Yassir Mahgoub
Mudi, Abdullahi
Khumalo, Tholang
Moonsamy, Glenda
Levy, Cecil
author_sort Bakhiet, Yassir Mahgoub
collection PubMed
description BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS. METHOD: Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed. RESULTS: Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2–6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%). CONCLUSION: There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports.
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spelling pubmed-58702662018-06-22 Idiopathic nephrotic syndrome in South African children Bakhiet, Yassir Mahgoub Mudi, Abdullahi Khumalo, Tholang Moonsamy, Glenda Levy, Cecil Afr Health Sci Articles BACKGROUND: Different histo-pathological types and treatment response patterns of Idiopathic nephrotic syndrome (INS) have been associated with differences in ethnicity and geographical location. OBJECTIVE: To provide an update on the steroid response and renal histo-pathological pattern in children treated for INS. METHOD: Medical records of children with INS treated at the Charlotte Maxeke Johannesburg Academic Hospital were reviewed. RESULTS: Mean age was 5.3 years ± 2.8. The majority (68.1%) of the 163 children were of the black racial group. The highest rate of INS was seen in the 2–6 year age group (71.2%). The black racial group had the highest rate (42/111; 37.8%) of focal segmental glomerulosclerosis (FSGS), and the white race had the highest rate (9/14; 64.3%) of minimal change disease (MCD). Ninety four (57.7%) patients were steroid sensitive (SSNS) while 69 patients (42.3%) were steroid resistant (SRNS). Minimal change disease was the most common histo-pathological type seen in SSNS (60%), while FSGS was the most common observed in patients who had SRNS (65.2%). CONCLUSION: There appears to be a higher rate of FSGS in all the racial groups, and also a higher rate of MCD in the black race group, when compared to previous reports. Makerere Medical School 2017-12 /pmc/articles/PMC5870266/ /pubmed/29937885 http://dx.doi.org/10.4314/ahs.v17i4.22 Text en © 2017 Bakhiet et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Bakhiet, Yassir Mahgoub
Mudi, Abdullahi
Khumalo, Tholang
Moonsamy, Glenda
Levy, Cecil
Idiopathic nephrotic syndrome in South African children
title Idiopathic nephrotic syndrome in South African children
title_full Idiopathic nephrotic syndrome in South African children
title_fullStr Idiopathic nephrotic syndrome in South African children
title_full_unstemmed Idiopathic nephrotic syndrome in South African children
title_short Idiopathic nephrotic syndrome in South African children
title_sort idiopathic nephrotic syndrome in south african children
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870266/
https://www.ncbi.nlm.nih.gov/pubmed/29937885
http://dx.doi.org/10.4314/ahs.v17i4.22
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