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Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei

BACKGROUND: Human African trypanosomiasis is one of the neglected and re-emerging infectious diseases in Africa with over 60 million people being at risk of contracting the disease. OBJECTIVE: To investigate the effects of Trypanosoma brucei brucei infection on secretion of adrenocorticotropic hormo...

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Autor principal: Maina, Charles Irungu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870269/
https://www.ncbi.nlm.nih.gov/pubmed/29937873
http://dx.doi.org/10.4314/ahs.v17i4.10
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author Maina, Charles Irungu
author_facet Maina, Charles Irungu
author_sort Maina, Charles Irungu
collection PubMed
description BACKGROUND: Human African trypanosomiasis is one of the neglected and re-emerging infectious diseases in Africa with over 60 million people being at risk of contracting the disease. OBJECTIVE: To investigate the effects of Trypanosoma brucei brucei infection on secretion of adrenocorticotropic hormone (ACTH) and histology of the pituitary gland and paraventricular nucleus in rats. METHODS: Rats were randomly divided into two groups, control and experimental. Experimental rats were injected intraperitonially with 0.2ml of blood containing 1.0 × 10(4) live T.b.brucei parasites. Tail blood samples were collected weekly for the determination of plasma concentration of ACTH. The pituitary gland and coronal section of brain were processed histologically and observed microscopically. RESULTS: There was a significant difference (p = 0.0190) in plasma ACTH concentration between the control and experimental rats. Histological alterations were observed in both the pituitary and paraventricular nucleus of experimental rats. CONCLUSION: T.b.brucei infection causes histological changes in both the paraventricular nucleus and pituitary gland in rats. These histological changes could account for the decrease in corticotropin releasing hormone (CRH) and ACTH production in the infected rats.
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spelling pubmed-58702692018-06-22 Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei Maina, Charles Irungu Afr Health Sci Articles BACKGROUND: Human African trypanosomiasis is one of the neglected and re-emerging infectious diseases in Africa with over 60 million people being at risk of contracting the disease. OBJECTIVE: To investigate the effects of Trypanosoma brucei brucei infection on secretion of adrenocorticotropic hormone (ACTH) and histology of the pituitary gland and paraventricular nucleus in rats. METHODS: Rats were randomly divided into two groups, control and experimental. Experimental rats were injected intraperitonially with 0.2ml of blood containing 1.0 × 10(4) live T.b.brucei parasites. Tail blood samples were collected weekly for the determination of plasma concentration of ACTH. The pituitary gland and coronal section of brain were processed histologically and observed microscopically. RESULTS: There was a significant difference (p = 0.0190) in plasma ACTH concentration between the control and experimental rats. Histological alterations were observed in both the pituitary and paraventricular nucleus of experimental rats. CONCLUSION: T.b.brucei infection causes histological changes in both the paraventricular nucleus and pituitary gland in rats. These histological changes could account for the decrease in corticotropin releasing hormone (CRH) and ACTH production in the infected rats. Makerere Medical School 2017-12 /pmc/articles/PMC5870269/ /pubmed/29937873 http://dx.doi.org/10.4314/ahs.v17i4.10 Text en © 2017 Maina CI. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Maina, Charles Irungu
Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title_full Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title_fullStr Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title_full_unstemmed Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title_short Plasma ACTH concentration and pituitary gland histo-pathology in rats infected with Trypanosoma brucei brucei
title_sort plasma acth concentration and pituitary gland histo-pathology in rats infected with trypanosoma brucei brucei
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870269/
https://www.ncbi.nlm.nih.gov/pubmed/29937873
http://dx.doi.org/10.4314/ahs.v17i4.10
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