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The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis

BACKGROUND: The reconstitution of cellular immune components contributes to clinical outcome of HIV and Mycobacterium tuberculosis (MTB) infection. Interruption of anti-retroviral therapy (ART) could lead to perturbations in reconstitution of T cells in HIV/ tuberculosis (TB) patients. OBJECTIVES: T...

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Autores principales: Nalukwago, Sophie, Lancioni, Christina L, Oketcho, Joy Baseke, Canaday, Dave H e, Boom, W Henry, Ojok, Lonzy, Mayanja-Kizza, Harriet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Makerere Medical School 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870287/
https://www.ncbi.nlm.nih.gov/pubmed/29937865
http://dx.doi.org/10.4314/ahs.v17i4.2
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author Nalukwago, Sophie
Lancioni, Christina L
Oketcho, Joy Baseke
Canaday, Dave H e
Boom, W Henry
Ojok, Lonzy
Mayanja-Kizza, Harriet
author_facet Nalukwago, Sophie
Lancioni, Christina L
Oketcho, Joy Baseke
Canaday, Dave H e
Boom, W Henry
Ojok, Lonzy
Mayanja-Kizza, Harriet
author_sort Nalukwago, Sophie
collection PubMed
description BACKGROUND: The reconstitution of cellular immune components contributes to clinical outcome of HIV and Mycobacterium tuberculosis (MTB) infection. Interruption of anti-retroviral therapy (ART) could lead to perturbations in reconstitution of T cells in HIV/ tuberculosis (TB) patients. OBJECTIVES: To ascertain the effect of interrupted ART on reconstitution of CD4(+) and CD8(+) T sub-sets in TB patients. METHODS: Participants with HIV (CD4>350 cells/µL) and TB were recruited under a larger phase 3 open label randomised controlled clinical trial. The CD45RO and CD62L markers were measured on CD4(+) and CD8(+) cells by flow cytometry. Samples were analysed at baseline, 3, 6, 12 months. RESULTS: There was a significant increase of naive CD8(+) cells (p = 0.003) and a decrease in effector CD8(+) cells (p = 0.004) among participants in ART/TB treatment arm during the first 6 months. Withdrawing ART led to naive CD8(+) cells reduction (p=0.02) to values close to baseline. An increase of naive CD8(+) cells after 6 months of TB treatment in TB alone treatment arm (p=0.01) was observed. A trend towards increment of naive CD4(+) sub sets in either treatment arms was observed. CONCLUSION: Interrupting ART alters CD8(+) but not CD4(+) sub-sets in patients with less advanced HIV infection and TB.
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spelling pubmed-58702872018-06-22 The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis Nalukwago, Sophie Lancioni, Christina L Oketcho, Joy Baseke Canaday, Dave H e Boom, W Henry Ojok, Lonzy Mayanja-Kizza, Harriet Afr Health Sci Articles BACKGROUND: The reconstitution of cellular immune components contributes to clinical outcome of HIV and Mycobacterium tuberculosis (MTB) infection. Interruption of anti-retroviral therapy (ART) could lead to perturbations in reconstitution of T cells in HIV/ tuberculosis (TB) patients. OBJECTIVES: To ascertain the effect of interrupted ART on reconstitution of CD4(+) and CD8(+) T sub-sets in TB patients. METHODS: Participants with HIV (CD4>350 cells/µL) and TB were recruited under a larger phase 3 open label randomised controlled clinical trial. The CD45RO and CD62L markers were measured on CD4(+) and CD8(+) cells by flow cytometry. Samples were analysed at baseline, 3, 6, 12 months. RESULTS: There was a significant increase of naive CD8(+) cells (p = 0.003) and a decrease in effector CD8(+) cells (p = 0.004) among participants in ART/TB treatment arm during the first 6 months. Withdrawing ART led to naive CD8(+) cells reduction (p=0.02) to values close to baseline. An increase of naive CD8(+) cells after 6 months of TB treatment in TB alone treatment arm (p=0.01) was observed. A trend towards increment of naive CD4(+) sub sets in either treatment arms was observed. CONCLUSION: Interrupting ART alters CD8(+) but not CD4(+) sub-sets in patients with less advanced HIV infection and TB. Makerere Medical School 2017-12 /pmc/articles/PMC5870287/ /pubmed/29937865 http://dx.doi.org/10.4314/ahs.v17i4.2 Text en © 2017 Nalukwago et al. Licensee African Health Sciences. This is an Open Access article distributed under the terms of the Creative commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Nalukwago, Sophie
Lancioni, Christina L
Oketcho, Joy Baseke
Canaday, Dave H e
Boom, W Henry
Ojok, Lonzy
Mayanja-Kizza, Harriet
The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title_full The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title_fullStr The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title_full_unstemmed The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title_short The effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive T cells during tuberculosis treatment in HIV patients with active pulmonary tuberculosis
title_sort effect of interrupted anti-retroviral treatment on the reconstitution of memory and naive t cells during tuberculosis treatment in hiv patients with active pulmonary tuberculosis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870287/
https://www.ncbi.nlm.nih.gov/pubmed/29937865
http://dx.doi.org/10.4314/ahs.v17i4.2
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