Cargando…

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

BACKGROUND: TREM2 is an innate immune receptor specifically expressed in microglia. Coding variations in TREM2 have been reported to increase the risk for Alzheimer’s disease (AD) and other neurodegenerative diseases. While multiple studies support a role for TREM2 in microglial recruitment to amylo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Li, Wang, Zongqi, Wang, Daxin, Wang, Zhe, Martens, Yuka A., Wu, Linbei, Xu, Ying, Wang, Kai, Li, Jianguo, Huang, Ruizhi, Can, Dan, Xu, Huaxi, Bu, Guojun, Chen, Xiao-Fen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870375/ https://www.ncbi.nlm.nih.gov/pubmed/29587871 http://dx.doi.org/10.1186/s13024-018-0247-7

Ejemplares similares

Soluble TREM2 induces inflammatory responses and enhances microglial survival
por: Zhong, Li, et al.
Publicado: (2017)

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology
por: Sheng, Xuan, et al.
Publicado: (2021)

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
por: Zhong, Li, et al.
Publicado: (2019)

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities
por: Liu, Zhaoji, et al.
Publicado: (2020)

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway
por: Zhong, Li, et al.
Publicado: (2017)

TREM2 in CNS homeostasis and neurodegenerative disease
por: Painter, Meghan M., et al.
Publicado: (2015)

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
por: Yang, Longyu, et al.
Publicado: (2016)

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
por: Qiao, Wenhui, et al.
Publicado: (2023)

Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
por: Qiao, Wenhui, et al.
Publicado: (2023)

TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration
por: Xie, Manling, et al.
Publicado: (2021)

Intracellular trafficking of TREM2 is regulated by presenilin 1
por: Zhao, Yingjun, et al.
Publicado: (2017)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
por: Zhao, Na, et al.
Publicado: (2022)

Regulating amyloidogenesis through the natural triggering receptor expressed in myeloid/microglial cells 2 (TREM2)
por: Jones, Brandon M., et al.
Publicado: (2014)

Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke
por: Li, Ping, et al.
Publicado: (2021)

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival
por: Cheng, Baoying, et al.
Publicado: (2021)

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism
por: Zheng, Honghua, et al.
Publicado: (2018)

Maprotiline ameliorates isoflurane-induced microglial activation via regulating triggering receptor expressed in myeloid cells 2 (TREM2)
por: Hu, Rui, et al.
Publicado: (2021)

Function of TREM1 and TREM2 in Liver-Related Diseases
por: Sun, Huifang, et al.
Publicado: (2020)

TREM2 triggers microglial density and age‐related neuronal loss
por: Linnartz‐Gerlach, Bettina, et al.
Publicado: (2018)

Author Correction: Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke
por: Li, Ping, et al.
Publicado: (2021)

APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease
por: Nguyen, Aivi T., et al.
Publicado: (2020)

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice
por: Xu, Xiaotian, et al.
Publicado: (2021)

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region
por: Schlepckow, Kai, et al.
Publicado: (2020)

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism
por: Zhong, Li, et al.
Publicado: (2016)

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
por: Xiang, Xianyuan, et al.
Publicado: (2016)

TREM2 Expression and Amyloid-Beta Phagocytosis in Alzheimer’s Disease
por: La Rosa, Francesca, et al.
Publicado: (2023)

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
por: Ulrich, Jason D, et al.
Publicado: (2014)

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
por: Sayed, Faten A., et al.
Publicado: (2018)

TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage
por: Hu, Yangchun, et al.
Publicado: (2021)

TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder
por: You, Yun-Fan, et al.
Publicado: (2023)

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
por: Wang, Na, et al.
Publicado: (2022)

Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma
por: Peshoff, Mekenzie M., et al.
Publicado: (2023)

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation
por: Hu, Jin, et al.
Publicado: (2015)

Tumor-Infiltrating Myeloid Cells Co-Express TREM1 and TREM2 and Elevated TREM-1 Associates With Disease Progression in Renal Cell Carcinoma
por: Ford, Jill W., et al.
Publicado: (2022)

Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases
por: Konishi, Hiroyuki, et al.
Publicado: (2018)

CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection
por: Gisslén, Magnus, et al.
Publicado: (2018)

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
por: Zhao, Peng, et al.
Publicado: (2022)

Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
por: Zhu, Bing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_c1srppd8dmma7kvsv039as45e9