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CATS (Coordinates of Atoms by Taylor Series): protein design with backbone flexibility in all locally feasible directions
MOTIVATION: When proteins mutate or bind to ligands, their backbones often move significantly, especially in loop regions. Computational protein design algorithms must model these motions in order to accurately optimize protein stability and binding affinity. However, methods for backbone conformati...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870559/ https://www.ncbi.nlm.nih.gov/pubmed/28882005 http://dx.doi.org/10.1093/bioinformatics/btx277 |