Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis

Renal ischemia-reperfusion is a main cause of acute kidney injury (AKI), which is associated with high mortality. Here we show that extracellular vesicles (EVs) secreted from hiPSC-MSCs play a critical role in protection against renal I/R injury. hiPSC-MSCs-EVs can fuse with renal cells and deliver...

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Detalles Bibliográficos
Autores principales: Yuan, Xiaodong, Li, Dawei, Chen, Xiaosong, Han, Conghui, Xu, Longmei, Huang, Tao, Dong, Zhen, Zhang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870585/
https://www.ncbi.nlm.nih.gov/pubmed/29233979
http://dx.doi.org/10.1038/s41419-017-0041-4

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