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Stroke-induced immunosuppression and poststroke infection
Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870641/ https://www.ncbi.nlm.nih.gov/pubmed/29600006 http://dx.doi.org/10.1136/svn-2017-000123 |
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author | Shi, Kaibin Wood, Kristofer Shi, Fu-Dong Wang, Xiaoying Liu, Qiang |
author_facet | Shi, Kaibin Wood, Kristofer Shi, Fu-Dong Wang, Xiaoying Liu, Qiang |
author_sort | Shi, Kaibin |
collection | PubMed |
description | Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system. |
format | Online Article Text |
id | pubmed-5870641 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58706412018-03-29 Stroke-induced immunosuppression and poststroke infection Shi, Kaibin Wood, Kristofer Shi, Fu-Dong Wang, Xiaoying Liu, Qiang Stroke Vasc Neurol Review Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system. BMJ Publishing Group 2018-01-12 /pmc/articles/PMC5870641/ /pubmed/29600006 http://dx.doi.org/10.1136/svn-2017-000123 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Review Shi, Kaibin Wood, Kristofer Shi, Fu-Dong Wang, Xiaoying Liu, Qiang Stroke-induced immunosuppression and poststroke infection |
title | Stroke-induced immunosuppression and poststroke infection |
title_full | Stroke-induced immunosuppression and poststroke infection |
title_fullStr | Stroke-induced immunosuppression and poststroke infection |
title_full_unstemmed | Stroke-induced immunosuppression and poststroke infection |
title_short | Stroke-induced immunosuppression and poststroke infection |
title_sort | stroke-induced immunosuppression and poststroke infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870641/ https://www.ncbi.nlm.nih.gov/pubmed/29600006 http://dx.doi.org/10.1136/svn-2017-000123 |
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