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Stroke-induced immunosuppression and poststroke infection

Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a...

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Autores principales: Shi, Kaibin, Wood, Kristofer, Shi, Fu-Dong, Wang, Xiaoying, Liu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870641/
https://www.ncbi.nlm.nih.gov/pubmed/29600006
http://dx.doi.org/10.1136/svn-2017-000123
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author Shi, Kaibin
Wood, Kristofer
Shi, Fu-Dong
Wang, Xiaoying
Liu, Qiang
author_facet Shi, Kaibin
Wood, Kristofer
Shi, Fu-Dong
Wang, Xiaoying
Liu, Qiang
author_sort Shi, Kaibin
collection PubMed
description Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system.
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spelling pubmed-58706412018-03-29 Stroke-induced immunosuppression and poststroke infection Shi, Kaibin Wood, Kristofer Shi, Fu-Dong Wang, Xiaoying Liu, Qiang Stroke Vasc Neurol Review Infections occur commonly after stroke and are strongly associated with an unfavourable functional outcome of these patients. Approaches for effective management of poststroke infection remain scarce, presenting an urgent need for preventive anti-infection strategies for patients who have suffered a stroke. Emerging evidence indicates that stroke impairs systemic immune responses and increases the susceptibility to infections, suggesting that the modification of impaired immune defence could be beneficial. In this review, we summarised previous attempts to prevent poststroke infections using prophylactic antibiotics and the current understanding of stroke-induced immunosuppression. Further elucidation of the immune mechanisms of stroke will pave the way to tailored design of new treatment to combat poststroke infection via modifying the immune system. BMJ Publishing Group 2018-01-12 /pmc/articles/PMC5870641/ /pubmed/29600006 http://dx.doi.org/10.1136/svn-2017-000123 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Shi, Kaibin
Wood, Kristofer
Shi, Fu-Dong
Wang, Xiaoying
Liu, Qiang
Stroke-induced immunosuppression and poststroke infection
title Stroke-induced immunosuppression and poststroke infection
title_full Stroke-induced immunosuppression and poststroke infection
title_fullStr Stroke-induced immunosuppression and poststroke infection
title_full_unstemmed Stroke-induced immunosuppression and poststroke infection
title_short Stroke-induced immunosuppression and poststroke infection
title_sort stroke-induced immunosuppression and poststroke infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870641/
https://www.ncbi.nlm.nih.gov/pubmed/29600006
http://dx.doi.org/10.1136/svn-2017-000123
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