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Tumor phylogeny inference using tree-constrained importance sampling
MOTIVATION: A tumor arises from an evolutionary process that can be modeled as a phylogenetic tree. However, reconstructing this tree is challenging as most cancer sequencing uses bulk tumor tissue containing heterogeneous mixtures of cells. RESULTS: We introduce Probabilistic Algorithm for Somatic...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870673/ https://www.ncbi.nlm.nih.gov/pubmed/28882002 http://dx.doi.org/10.1093/bioinformatics/btx270 |