WIsH: who is the host? Predicting prokaryotic hosts from metagenomic phage contigs

SUMMARY: WIsH predicts prokaryotic hosts of phages from their genomic sequences. It achieves 63% mean accuracy when predicting the host genus among 20 genera for 3 kbp-long phage contigs. Over the best current tool, WisH shows much improved accuracy on phage sequences of a few kbp length and runs hu...

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Detalles Bibliográficos
Autores principales: Galiez, Clovis, Siebert, Matthias, Enault, François, Vincent, Jonathan, Söding, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870724/
https://www.ncbi.nlm.nih.gov/pubmed/28957499
http://dx.doi.org/10.1093/bioinformatics/btx383
Descripción
Sumario:SUMMARY: WIsH predicts prokaryotic hosts of phages from their genomic sequences. It achieves 63% mean accuracy when predicting the host genus among 20 genera for 3 kbp-long phage contigs. Over the best current tool, WisH shows much improved accuracy on phage sequences of a few kbp length and runs hundreds of times faster, making it suited for metagenomics studies. AVAILABILITY AND IMPLEMENTATION: OpenMP-parallelized GPL-licensed C ++ code available at https://github.com/soedinglab/wish. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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