LASER server: ancestry tracing with genotypes or sequence reads

SUMMARY: To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sampl...

Descripción completa

Detalles Bibliográficos
Autores principales: Taliun, Daniel, Chothani, Sonia P, Schönherr, Sebastian, Forer, Lukas, Boehnke, Michael, Abecasis, Gonçalo R, Wang, Chaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870850/
https://www.ncbi.nlm.nih.gov/pubmed/28200055
http://dx.doi.org/10.1093/bioinformatics/btx075
Descripción
Sumario:SUMMARY: To enable direct comparison of ancestry background in different studies, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or genotyping array used to characterize each sample. Here we describe the LASER server to facilitate application of the method to a wide range of genetic studies. The server provides genetic ancestry estimation for different geographic regions and user-friendly interactive visualization of the results. AVAILABILITY AND IMPLEMENTATION: The LASER server is freely accessible at http://laser.sph.umich.edu/ SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Ejemplares similares