DNA sequence+shape kernel enables alignment-free modeling of transcription factor binding

MOTIVATION: Transcription factors (TFs) bind to specific DNA sequence motifs. Several lines of evidence suggest that TF-DNA binding is mediated in part by properties of the local DNA shape: the width of the minor groove, the relative orientations of adjacent base pairs, etc. Several methods have bee...

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Detalles Bibliográficos
Autores principales: Ma, Wenxiu, Yang, Lin, Rohs, Remo, Noble, William Stafford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870879/
https://www.ncbi.nlm.nih.gov/pubmed/28541376
http://dx.doi.org/10.1093/bioinformatics/btx336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870879/
https://www.ncbi.nlm.nih.gov/pubmed/28541376
http://dx.doi.org/10.1093/bioinformatics/btx336

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