Cargando…

Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis

BACKGROUND: Hashimoto’s thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto’s thyr...

Descripción completa

Detalles Bibliográficos
Autores principales: Farhangi, Mahdieh Abbasalizad, Dehghan, Parvin, Tajmiri, Siroos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870944/
https://www.ncbi.nlm.nih.gov/pubmed/29587770
http://dx.doi.org/10.1186/s12944-018-0704-x
_version_ 1783309569099825152
author Farhangi, Mahdieh Abbasalizad
Dehghan, Parvin
Tajmiri, Siroos
author_facet Farhangi, Mahdieh Abbasalizad
Dehghan, Parvin
Tajmiri, Siroos
author_sort Farhangi, Mahdieh Abbasalizad
collection PubMed
description BACKGROUND: Hashimoto’s thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto’s thyroiditis. METHODS: Forty patients with Hashimoto’s thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks. Serum lipids, glucose homeostasis, and anthropometric variables were evaluated at baseline and after intervention. RESULTS: Treatment with Nigella sativa significantly reduced body weight and body mass index (BMI). Serum concentrations of low density lipoprotein cholesterol (LDL) and triglyceride (TG) also decreased in Nigella sativa-treated group after 8 weeks; while serum high density lipoprotein cholesterol (HDL) significantly increased after treatment with Nigella sativa (P < 0.05). None of these changes had been observed in placebo treated group. Serum Nesfatin-1 concentrations was in inverse relationship with serum triglyceride (TG) (r = − 0.31, P = 0.04). CONCLUSIONS: Giving attention to the potent beneficial effects of powdered black cumin seeds in improving serum lipid profile and anthropometric features in patients with Hashimoto’s thyroiditis, this medicinal plant could be considered as a beneficial herbal supplement alongside with the disease- specific medications including Levothyroxine in management of Hashimoto’s thyroiditis- related metabolic abnormalities. TRIAL REGISTRATION: Iranian registry of clinical trials (registration number IRCT2014090819082N2- Registered 2014-09-29).
format Online
Article
Text
id pubmed-5870944
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-58709442018-04-02 Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis Farhangi, Mahdieh Abbasalizad Dehghan, Parvin Tajmiri, Siroos Lipids Health Dis Research BACKGROUND: Hashimoto’s thyroiditis is associated with serious alterations in serum lipids and glucose homeostasis. The aims of the current study were to evaluate the effect of powdered Nigella sativa on serum lipids, glucose homeostasis and anthropometric variables in patients with Hashimoto’s thyroiditis. METHODS: Forty patients with Hashimoto’s thyroiditis, aged between 22 and 50 years old, participated in the trial and were randomly allocated into two groups of intervention and control receiving powdered Nigella sativa or placebo daily for 8 weeks. Serum lipids, glucose homeostasis, and anthropometric variables were evaluated at baseline and after intervention. RESULTS: Treatment with Nigella sativa significantly reduced body weight and body mass index (BMI). Serum concentrations of low density lipoprotein cholesterol (LDL) and triglyceride (TG) also decreased in Nigella sativa-treated group after 8 weeks; while serum high density lipoprotein cholesterol (HDL) significantly increased after treatment with Nigella sativa (P < 0.05). None of these changes had been observed in placebo treated group. Serum Nesfatin-1 concentrations was in inverse relationship with serum triglyceride (TG) (r = − 0.31, P = 0.04). CONCLUSIONS: Giving attention to the potent beneficial effects of powdered black cumin seeds in improving serum lipid profile and anthropometric features in patients with Hashimoto’s thyroiditis, this medicinal plant could be considered as a beneficial herbal supplement alongside with the disease- specific medications including Levothyroxine in management of Hashimoto’s thyroiditis- related metabolic abnormalities. TRIAL REGISTRATION: Iranian registry of clinical trials (registration number IRCT2014090819082N2- Registered 2014-09-29). BioMed Central 2018-03-27 /pmc/articles/PMC5870944/ /pubmed/29587770 http://dx.doi.org/10.1186/s12944-018-0704-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Farhangi, Mahdieh Abbasalizad
Dehghan, Parvin
Tajmiri, Siroos
Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title_full Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title_fullStr Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title_full_unstemmed Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title_short Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto’s thyroiditis
title_sort powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with hashimoto’s thyroiditis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870944/
https://www.ncbi.nlm.nih.gov/pubmed/29587770
http://dx.doi.org/10.1186/s12944-018-0704-x
work_keys_str_mv AT farhangimahdiehabbasalizad powderedblackcuminseedsstronglyimprovesserumlipidsatherogenicindexofplasmaandmodulatesanthropometricfeaturesinpatientswithhashimotosthyroiditis
AT dehghanparvin powderedblackcuminseedsstronglyimprovesserumlipidsatherogenicindexofplasmaandmodulatesanthropometricfeaturesinpatientswithhashimotosthyroiditis
AT tajmirisiroos powderedblackcuminseedsstronglyimprovesserumlipidsatherogenicindexofplasmaandmodulatesanthropometricfeaturesinpatientswithhashimotosthyroiditis