Cargando…

Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu

Rasa Shastra is an exclusive branch of ayurveda that uses processed metals and minerals in various combinations. Though the formulations are time tested, safety and quality concerns are being raised since the past two decades. In view of this, it becomes mandatory to generate quality control profile...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Arjun, Ota, Sarada, Srikanth, Narayan, Galib, Ruknuddin, Bojja, Sreedhar, Dhiman, Kartar Sing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871055/
https://www.ncbi.nlm.nih.gov/pubmed/29405758
http://dx.doi.org/10.1177/2156587217751761
_version_ 1783309593547374592
author Singh, Arjun
Ota, Sarada
Srikanth, Narayan
Galib, Ruknuddin
Bojja, Sreedhar
Dhiman, Kartar Sing
author_facet Singh, Arjun
Ota, Sarada
Srikanth, Narayan
Galib, Ruknuddin
Bojja, Sreedhar
Dhiman, Kartar Sing
author_sort Singh, Arjun
collection PubMed
description Rasa Shastra is an exclusive branch of ayurveda that uses processed metals and minerals in various combinations. Though the formulations are time tested, safety and quality concerns are being raised since the past two decades. In view of this, it becomes mandatory to generate quality control profiles of such formulations by following available parameters. Considering this, we attempted to develop standard manufacturing procedures of Maha Yogaraja Guggulu and generate preliminary physicochemical profiles using inductively coupled plasma mass spectrometry, X-ray diffraction, and high-performance thin-layer chromatography. The results from high-performance thin-layer chromatography revealed presence of organic constituents from plant material. X-ray diffraction indicated that the prepared drug contained cinnabar (mercury sulfide; Rasa sindhura), cassiterite (tin oxide; Vanga bhasma), litharge (lead oxide; Naga bhasma), and iron dioxide and magnetite (di-iron oxide; Loha and Mandura bhasma). The observations of the present study are preliminary and first of its kind that may be considered as baseline data for future studies.
format Online
Article
Text
id pubmed-5871055
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-58710552018-04-02 Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu Singh, Arjun Ota, Sarada Srikanth, Narayan Galib, Ruknuddin Bojja, Sreedhar Dhiman, Kartar Sing J Evid Based Integr Med Original Article Rasa Shastra is an exclusive branch of ayurveda that uses processed metals and minerals in various combinations. Though the formulations are time tested, safety and quality concerns are being raised since the past two decades. In view of this, it becomes mandatory to generate quality control profiles of such formulations by following available parameters. Considering this, we attempted to develop standard manufacturing procedures of Maha Yogaraja Guggulu and generate preliminary physicochemical profiles using inductively coupled plasma mass spectrometry, X-ray diffraction, and high-performance thin-layer chromatography. The results from high-performance thin-layer chromatography revealed presence of organic constituents from plant material. X-ray diffraction indicated that the prepared drug contained cinnabar (mercury sulfide; Rasa sindhura), cassiterite (tin oxide; Vanga bhasma), litharge (lead oxide; Naga bhasma), and iron dioxide and magnetite (di-iron oxide; Loha and Mandura bhasma). The observations of the present study are preliminary and first of its kind that may be considered as baseline data for future studies. SAGE Publications 2018-02-01 /pmc/articles/PMC5871055/ /pubmed/29405758 http://dx.doi.org/10.1177/2156587217751761 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Singh, Arjun
Ota, Sarada
Srikanth, Narayan
Galib, Ruknuddin
Bojja, Sreedhar
Dhiman, Kartar Sing
Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title_full Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title_fullStr Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title_full_unstemmed Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title_short Application of Spectroscopic and Chromatographic Methods for Chemical Characterization of an Ayurvedic Herbo-Mineral Preparation: Maha Yograja Guggulu
title_sort application of spectroscopic and chromatographic methods for chemical characterization of an ayurvedic herbo-mineral preparation: maha yograja guggulu
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871055/
https://www.ncbi.nlm.nih.gov/pubmed/29405758
http://dx.doi.org/10.1177/2156587217751761
work_keys_str_mv AT singharjun applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu
AT otasarada applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu
AT srikanthnarayan applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu
AT galibruknuddin applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu
AT bojjasreedhar applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu
AT dhimankartarsing applicationofspectroscopicandchromatographicmethodsforchemicalcharacterizationofanayurvedicherbomineralpreparationmahayograjaguggulu