Cargando…

Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions

The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pur...

Descripción completa

Detalles Bibliográficos
Autores principales: Matotoka, Mash M., Masoko, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871308/
https://www.ncbi.nlm.nih.gov/pubmed/29228818
http://dx.doi.org/10.1177/2156587217727112
_version_ 1783309622809985024
author Matotoka, Mash M.
Masoko, Peter
author_facet Matotoka, Mash M.
Masoko, Peter
author_sort Matotoka, Mash M.
collection PubMed
description The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pure cultures. Nutritional content of the concoctions was determined. Thin layer chromatography was used to analyze the chemical constituents of the extracts. The microdilution assay and bioautography were used to evaluate antimicrobial activity against selected microorganisms. Sodium, potassium, and zinc were elements most abundant in the concoctions. Phytochemical screening revealed the presence of various phytoconstituents. Acetone extracts of Hypoxis hemerocallidea and Kirkia wilmsii extracts had antioxidant activity. The minimum inhibitory concentrations values against test bacteria ranged between 0.02 and 0.63 mg/mL. Further studies are required to isolate bioactive compounds and evaluate their cytotoxicity. Caution in the consumption of the herbal mixtures should be adhered to.
format Online
Article
Text
id pubmed-5871308
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-58713082018-04-02 Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions Matotoka, Mash M. Masoko, Peter J Evid Based Complementary Altern Med Original Articles The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pure cultures. Nutritional content of the concoctions was determined. Thin layer chromatography was used to analyze the chemical constituents of the extracts. The microdilution assay and bioautography were used to evaluate antimicrobial activity against selected microorganisms. Sodium, potassium, and zinc were elements most abundant in the concoctions. Phytochemical screening revealed the presence of various phytoconstituents. Acetone extracts of Hypoxis hemerocallidea and Kirkia wilmsii extracts had antioxidant activity. The minimum inhibitory concentrations values against test bacteria ranged between 0.02 and 0.63 mg/mL. Further studies are required to isolate bioactive compounds and evaluate their cytotoxicity. Caution in the consumption of the herbal mixtures should be adhered to. SAGE Publications 2017-09-28 2017-10 /pmc/articles/PMC5871308/ /pubmed/29228818 http://dx.doi.org/10.1177/2156587217727112 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Articles
Matotoka, Mash M.
Masoko, Peter
Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title_full Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title_fullStr Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title_full_unstemmed Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title_short Evaluation of Herbal Concoctions Sold at Ga Maja (Limpopo Province) in South Africa and In Vitro Pharmacological Evaluation of Plants Used to Manufacture the Concoctions
title_sort evaluation of herbal concoctions sold at ga maja (limpopo province) in south africa and in vitro pharmacological evaluation of plants used to manufacture the concoctions
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871308/
https://www.ncbi.nlm.nih.gov/pubmed/29228818
http://dx.doi.org/10.1177/2156587217727112
work_keys_str_mv AT matotokamashm evaluationofherbalconcoctionssoldatgamajalimpopoprovinceinsouthafricaandinvitropharmacologicalevaluationofplantsusedtomanufacturetheconcoctions
AT masokopeter evaluationofherbalconcoctionssoldatgamajalimpopoprovinceinsouthafricaandinvitropharmacologicalevaluationofplantsusedtomanufacturetheconcoctions