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Hyaluronic acid in dermatomyositis and polymyositis: relationship with disease and cutaneous lesions
BACKGROUND: There are scarce studies in the literature about hyaluronic acid in systemic autoimmune myopathies. OBJECTIVES: To analyze the serum level of hyaluronic acid in patients with dermatomyositis and polymyositis. METHODS: Cross-sectional study, single-center, that evaluated hyaluronic acid i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Dermatologia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871366/ https://www.ncbi.nlm.nih.gov/pubmed/29641701 http://dx.doi.org/10.1590/abd1806-4841.20186727 |
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author | Silva, Marilda Guimarães Shinjo, Samuel Katsuyuki |
author_facet | Silva, Marilda Guimarães Shinjo, Samuel Katsuyuki |
author_sort | Silva, Marilda Guimarães |
collection | PubMed |
description | BACKGROUND: There are scarce studies in the literature about hyaluronic acid in systemic autoimmune myopathies. OBJECTIVES: To analyze the serum level of hyaluronic acid in patients with dermatomyositis and polymyositis. METHODS: Cross-sectional study, single-center, that evaluated hyaluronic acid in 18 dermatomyositis and 15 polymyositis (Bohan and Peter criteria), newly diagnosed, with clinical and laboratory activity, with no previous drug treatment. The patients were also age-, gender- and ethnicity-matched to 36 healthy individuals. The hyaluronic acid was analyzed by ELISA/EIA kit anti-hyaluronic acid. RESULTS: There was a higher serum level of hyaluronic acid in patients with autoimmune myopathies, in relation to control group (P<0.05). Moreover, the serum level of this glycosaminoglycan was higher in dermatomyositis, when compared to polymyositis. Both groups were comparable with regard to demographic, clinical and laboratory data, except for the presence of skin lesions in the first group. STUDY LIMITATIONS. The presence of hyaluronic acid in cutaneous lesions, particularly of patients with dermatomyositis, was not analyzed neither quantified. In addition, due to disease rarity and the establishment of strict inclusion and exclusion criteria, there was a small sample in the present study. CONCLUSIONS: As an example of others systemic autoimmune diseases, it is possible that the hyaluronic acid is involved in the pathogenesis of autoimmune myopathies, and particularly when associated with cutaneous lesions. |
format | Online Article Text |
id | pubmed-5871366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-58713662018-03-29 Hyaluronic acid in dermatomyositis and polymyositis: relationship with disease and cutaneous lesions Silva, Marilda Guimarães Shinjo, Samuel Katsuyuki An Bras Dermatol Investigation BACKGROUND: There are scarce studies in the literature about hyaluronic acid in systemic autoimmune myopathies. OBJECTIVES: To analyze the serum level of hyaluronic acid in patients with dermatomyositis and polymyositis. METHODS: Cross-sectional study, single-center, that evaluated hyaluronic acid in 18 dermatomyositis and 15 polymyositis (Bohan and Peter criteria), newly diagnosed, with clinical and laboratory activity, with no previous drug treatment. The patients were also age-, gender- and ethnicity-matched to 36 healthy individuals. The hyaluronic acid was analyzed by ELISA/EIA kit anti-hyaluronic acid. RESULTS: There was a higher serum level of hyaluronic acid in patients with autoimmune myopathies, in relation to control group (P<0.05). Moreover, the serum level of this glycosaminoglycan was higher in dermatomyositis, when compared to polymyositis. Both groups were comparable with regard to demographic, clinical and laboratory data, except for the presence of skin lesions in the first group. STUDY LIMITATIONS. The presence of hyaluronic acid in cutaneous lesions, particularly of patients with dermatomyositis, was not analyzed neither quantified. In addition, due to disease rarity and the establishment of strict inclusion and exclusion criteria, there was a small sample in the present study. CONCLUSIONS: As an example of others systemic autoimmune diseases, it is possible that the hyaluronic acid is involved in the pathogenesis of autoimmune myopathies, and particularly when associated with cutaneous lesions. Sociedade Brasileira de Dermatologia 2018 /pmc/articles/PMC5871366/ /pubmed/29641701 http://dx.doi.org/10.1590/abd1806-4841.20186727 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way. |
spellingShingle | Investigation Silva, Marilda Guimarães Shinjo, Samuel Katsuyuki Hyaluronic acid in dermatomyositis and polymyositis: relationship with disease and cutaneous lesions |
title | Hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
title_full | Hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
title_fullStr | Hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
title_full_unstemmed | Hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
title_short | Hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
title_sort | hyaluronic acid in dermatomyositis and polymyositis: relationship
with disease and cutaneous lesions |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871366/ https://www.ncbi.nlm.nih.gov/pubmed/29641701 http://dx.doi.org/10.1590/abd1806-4841.20186727 |
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