Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)

Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria cutanea tarda fro...

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Autores principales: Succi, Isabella Brasil, Pôrto, Luís Cristóvão, Domingues, Patricia Mariana Gonçalves da Rocha Porto, Fonseca, João Carlos Macedo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871387/
https://www.ncbi.nlm.nih.gov/pubmed/29641722
http://dx.doi.org/10.1590/abd1806-4841.20186666
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author Succi, Isabella Brasil
Pôrto, Luís Cristóvão
Domingues, Patricia Mariana Gonçalves da Rocha Porto
Fonseca, João Carlos Macedo
author_facet Succi, Isabella Brasil
Pôrto, Luís Cristóvão
Domingues, Patricia Mariana Gonçalves da Rocha Porto
Fonseca, João Carlos Macedo
author_sort Succi, Isabella Brasil
collection PubMed
description Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria cutanea tarda from a mixed population. Thirty patients living in Rio de Janeiro with sporadic porphyria cutanea tarda were studied for the genetic ancestry through informative markers - INDELS. There was a significant predominance of European ancestry across the sample of patients with porphyria cutanea tarda (70.2%), and a small contribution of African and Amerindian ancestry, 20.1% and 10.9%, respectively.
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spelling pubmed-58713872018-03-29 Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil) Succi, Isabella Brasil Pôrto, Luís Cristóvão Domingues, Patricia Mariana Gonçalves da Rocha Porto Fonseca, João Carlos Macedo An Bras Dermatol Communication Porphyria cutanea tarda has a complex etiology with genetic factors not completely elucidated. The miscegenation of the Brazilian population has important implications in the predisposition to diseases. There are no studies concerning the genetic ancestry of patients with porphyria cutanea tarda from a mixed population. Thirty patients living in Rio de Janeiro with sporadic porphyria cutanea tarda were studied for the genetic ancestry through informative markers - INDELS. There was a significant predominance of European ancestry across the sample of patients with porphyria cutanea tarda (70.2%), and a small contribution of African and Amerindian ancestry, 20.1% and 10.9%, respectively. Sociedade Brasileira de Dermatologia 2018 /pmc/articles/PMC5871387/ /pubmed/29641722 http://dx.doi.org/10.1590/abd1806-4841.20186666 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.
spellingShingle Communication
Succi, Isabella Brasil
Pôrto, Luís Cristóvão
Domingues, Patricia Mariana Gonçalves da Rocha Porto
Fonseca, João Carlos Macedo
Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title_full Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title_fullStr Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title_full_unstemmed Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title_short Genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (Rio de Janeiro - Brazil)
title_sort genetic ancestry of patients with porphyria cutanea tarda in a country with mixed races: a cross-sectional study (rio de janeiro - brazil)
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871387/
https://www.ncbi.nlm.nih.gov/pubmed/29641722
http://dx.doi.org/10.1590/abd1806-4841.20186666
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