Distinct Immunologic Properties of Soluble Versus Particulate Antigens

Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is al...

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Detalles Bibliográficos
Autor principal: Snapper, Clifford M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871672/
https://www.ncbi.nlm.nih.gov/pubmed/29619034
http://dx.doi.org/10.3389/fimmu.2018.00598
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author Snapper, Clifford M.
author_facet Snapper, Clifford M.
author_sort Snapper, Clifford M.
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description Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is also relevant regarding the use of therapeutic human proteins in clinical medicine that have been shown to aggregate, and perhaps as a result, elicit autoantibodies.
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spelling pubmed-58716722018-04-04 Distinct Immunologic Properties of Soluble Versus Particulate Antigens Snapper, Clifford M. Front Immunol Immunology Antigens in particulate form have distinct immunologic properties relative to soluble antigens. An understanding of the mechanisms and functional consequences of the distinct immunologic pathways engaged by these different forms of antigen is particularly relevant to the design of vaccines. It is also relevant regarding the use of therapeutic human proteins in clinical medicine that have been shown to aggregate, and perhaps as a result, elicit autoantibodies. Frontiers Media S.A. 2018-03-21 /pmc/articles/PMC5871672/ /pubmed/29619034 http://dx.doi.org/10.3389/fimmu.2018.00598 Text en Copyright © 2018 Snapper. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Snapper, Clifford M.
Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title_full Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title_fullStr Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title_full_unstemmed Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title_short Distinct Immunologic Properties of Soluble Versus Particulate Antigens
title_sort distinct immunologic properties of soluble versus particulate antigens
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871672/
https://www.ncbi.nlm.nih.gov/pubmed/29619034
http://dx.doi.org/10.3389/fimmu.2018.00598
work_keys_str_mv AT snappercliffordm distinctimmunologicpropertiesofsolubleversusparticulateantigens

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