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S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic

S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversibl...

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Detalles Bibliográficos
Autores principales:	Kailing, Lyn L., Bertinetti, Daniela, Paul, Caroline E., Manszewski, Tomasz, Jaskolski, Mariusz, Herberg, Friedrich W., Pavlidis, Ioannis V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871694/ https://www.ncbi.nlm.nih.gov/pubmed/29619018 http://dx.doi.org/10.3389/fmicb.2018.00505

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