A licensing step links AID to transcription elongation for mutagenesis in B cells

Activation-induced deaminase (AID) mutates the immunoglobulin (Ig) genes to initiate somatic hypermutation (SHM) and class switch recombination (CSR) in B cells, thus underpinning antibody responses. AID mutates a few hundred other loci, but most AID-occupied genes are spared. The mechanisms underly...

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Detalles Bibliográficos
Autores principales: Methot, Stephen P., Litzler, Ludivine C., Subramani, Poorani Ganesh, Eranki, Anil K., Fifield, Heather, Patenaude, Anne-Marie, Gilmore, Julian C., Santiago, Gabriel E., Bagci, Halil, Côté, Jean-François, Larijani, Mani, Verdun, Ramiro E., Di Noia, Javier M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871760/
https://www.ncbi.nlm.nih.gov/pubmed/29593215
http://dx.doi.org/10.1038/s41467-018-03387-6

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