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An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

A crucial issue for Treg-based immunotherapy is to maintain a bona fide Treg phenotype as well as suppressive function during and after ex vivo expansion. Several strategies have been applied to harness Treg lineage stability. For instance, CD28 superagonist stimulation in vitro, in the absence of C...

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Detalles Bibliográficos
Autores principales:	Urbano, Paulo C. M., Koenen, Hans J. P. M., Joosten, Irma, He, Xuehui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871762/ https://www.ncbi.nlm.nih.gov/pubmed/29619032 http://dx.doi.org/10.3389/fimmu.2018.00573

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