Cargando…

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one of the most studied transmembrane cell signaling pathways. However, it is unknown whether the ligand-dependent interactions between these signaling molecules are based on random collisions or the rearrangement of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Navarro, Gemma, Cordomí, Arnau, Casadó-Anguera, Verónica, Moreno, Estefanía, Cai, Ning-Sheng, Cortés, Antoni, Canela, Enric I., Dessauer, Carmen W., Casadó, Vicent, Pardo, Leonardo, Lluís, Carme, Ferré, Sergi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871782/ https://www.ncbi.nlm.nih.gov/pubmed/29593213 http://dx.doi.org/10.1038/s41467-018-03522-3

Ejemplares similares

Essential Control of the Function of the Striatopallidal Neuron by Pre-coupled Complexes of Adenosine A(2A)-Dopamine D(2) Receptor Heterotetramers and Adenylyl Cyclase
por: Ferré, Sergi, et al.
Publicado: (2018)

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function
por: Ferré, Sergi, et al.
Publicado: (2011)

Cocaine Inhibits Dopamine D(2) Receptor Signaling via Sigma-1-D(2) Receptor Heteromers
por: Navarro, Gemma, et al.
Publicado: (2013)

Cross-communication between G(i) and G(s) in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
por: Navarro, Gemma, et al.
Publicado: (2018)

Detection of Heteromers Formed by Cannabinoid CB(1), Dopamine D(2), and Adenosine A(2A) G-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer
por: Navarro, Gemma, et al.
Publicado: (2008)

Significant Functional Differences Between Dopamine D(4) Receptor Polymorphic Variants Upon Heteromerization with α(1A) Adrenoreceptors
por: Homar-Ruano, Patricia, et al.
Publicado: (2023)

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB(1) and Serotonin 5-HT(2A) Receptors
por: Viñals, Xavier, et al.
Publicado: (2015)

Basic Concepts in G-Protein-Coupled Receptor Homo- and Heterodimerization
por: Franco, Rafael, et al.
Publicado: (2007)

Function of Adenylyl Cyclase in Heart: the AKAP Connection
por: Baldwin, Tanya A., et al.
Publicado: (2018)

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with G(i) and G(s)
por: Navarro, Gemma, et al.
Publicado: (2016)

Molecular Evidence of Adenosine Deaminase Linking Adenosine A(2A) Receptor and CD26 Proteins
por: Moreno, Estefanía, et al.
Publicado: (2018)

Circadian-Related Heteromerization of Adrenergic and Dopamine D(4) Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland
por: González, Sergio, et al.
Publicado: (2012)

Structural basis of adenylyl cyclase 9 activation
por: Qi, Chao, et al.
Publicado: (2022)

Striatal Pre- and Postsynaptic Profile of Adenosine A(2A) Receptor Antagonists
por: Orru, Marco, et al.
Publicado: (2011)

Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
por: Yen, Yu-Chen, et al.
Publicado: (2023)

G protein-regulated endocytic trafficking of adenylyl cyclase type 9
por: Lazar, André M, et al.
Publicado: (2020)

Control of glutamate release by complexes of adenosine and cannabinoid receptors
por: Köfalvi, Attila, et al.
Publicado: (2020)

Adenosine Receptor Heteromers and their Integrative Role in Striatal Function
por: Ferré, Sergi, et al.
Publicado: (2007)

Regulation of I(Ks) Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase
por: Li, Yong, et al.
Publicado: (2019)

Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction
por: Li, Yong, et al.
Publicado: (2017)

New Perspectives on Plant Adenylyl Cyclases
por: Ruzvidzo, Oziniel, et al.
Publicado: (2019)

Expression and functions of adenylyl cyclases in the CNS
por: Devasani, Karan, et al.
Publicado: (2022)

Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs
por: Franco, Rafael, et al.
Publicado: (2023)

Singular Location and Signaling Profile of Adenosine A(2A)-Cannabinoid CB(1) Receptor Heteromers in the Dorsal Striatum
por: Moreno, Estefanía, et al.
Publicado: (2018)

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?
por: Moreno, Estefanía, et al.
Publicado: (2019)

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6
por: Bull Melsom, Caroline, et al.
Publicado: (2019)

POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK‐1 in heart
por: Baldwin, Tanya A, et al.
Publicado: (2022)

Activation of adenylyl cyclase in Chlamydomonas reinhardtii by adhesion and by heat
Publicado: (1993)

Soluble adenylyl cyclase is essential for proper lysosomal acidification
por: Rahman, Nawreen, et al.
Publicado: (2016)

Editorial: Adenylyl cyclase isoforms as potential drug targets
por: Brust, Tarsis F., et al.
Publicado: (2022)

Dopamine D(4) receptor, but not the ADHD-associated D(4.7) variant, forms functional heteromers with the dopamine D(2S) receptor in the brain
por: González, Sergio, et al.
Publicado: (2011)

Human adenylyl cyclase 9 is auto-stimulated by its isoform-specific C-terminal domain
por: Chen, Zhihao, et al.
Publicado: (2023)

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese
por: Wang, Zhenshan, et al.
Publicado: (2009)

Spatial resolution of cAMP signaling by soluble adenylyl cyclase
por: Caldieri, Giusi, et al.
Publicado: (2016)

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex
por: Tarnawski, Laura, et al.
Publicado: (2018)

Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia
por: Chen, Si-Liang, et al.
Publicado: (2020)

The evolutionary conservation of eukaryotic membrane-bound adenylyl cyclase isoforms
por: Schultz, Joachim E.
Publicado: (2022)

Gα(s), adenylyl cyclase, and their relationship to the diagnosis and treatment of depression
por: Schappi, Jeffrey M., et al.
Publicado: (2022)

Characterization of Adenylyl Cyclase Isoform 6 Residues Interacting with Forskolin
por: Bhatia, Vikram, et al.
Publicado: (2023)

Modulation of dopamine D(1) receptors via histamine H(3) receptors is a novel therapeutic target for Huntington's disease
por: Moreno-Delgado, David, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1m1lnajc5oqupb2iludh9gfcqq