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Quantum probe hyperpolarisation of molecular nuclear spins

Hyperpolarisation of nuclear spins is important in overcoming sensitivity and resolution limitations of magnetic resonance imaging and nuclear magnetic resonance spectroscopy. Current hyperpolarisation techniques require high magnetic fields, low temperatures, or catalysts. Alternatively, the emerge...

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Detalles Bibliográficos
Autores principales: Broadway, David A., Tetienne, Jean-Philippe, Stacey, Alastair, Wood, James D. A., Simpson, David A., Hall, Liam T., Hollenberg, Lloyd C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871805/
https://www.ncbi.nlm.nih.gov/pubmed/29593304
http://dx.doi.org/10.1038/s41467-018-03578-1
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author Broadway, David A.
Tetienne, Jean-Philippe
Stacey, Alastair
Wood, James D. A.
Simpson, David A.
Hall, Liam T.
Hollenberg, Lloyd C. L.
author_facet Broadway, David A.
Tetienne, Jean-Philippe
Stacey, Alastair
Wood, James D. A.
Simpson, David A.
Hall, Liam T.
Hollenberg, Lloyd C. L.
author_sort Broadway, David A.
collection PubMed
description Hyperpolarisation of nuclear spins is important in overcoming sensitivity and resolution limitations of magnetic resonance imaging and nuclear magnetic resonance spectroscopy. Current hyperpolarisation techniques require high magnetic fields, low temperatures, or catalysts. Alternatively, the emergence of room temperature spin qubits has opened new pathways to achieve direct nuclear spin hyperpolarisation. Employing a microwave-free cross-relaxation induced polarisation protocol applied to a nitrogen vacancy qubit, we demonstrate quantum probe hyperpolarisation of external molecular nuclear spins to ~50% under ambient conditions, showing a single qubit increasing the polarisation of ~10(6) nuclear spins by six orders of magnitude over the thermal background. Results are verified against a detailed theoretical treatment, which also describes how the system can be scaled up to a universal quantum hyperpolarisation platform for macroscopic samples. Our results demonstrate the prospects for this approach to nuclear spin hyperpolarisation for molecular imaging and spectroscopy and its potential to extend beyond into other scientific areas.
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spelling pubmed-58718052018-03-29 Quantum probe hyperpolarisation of molecular nuclear spins Broadway, David A. Tetienne, Jean-Philippe Stacey, Alastair Wood, James D. A. Simpson, David A. Hall, Liam T. Hollenberg, Lloyd C. L. Nat Commun Article Hyperpolarisation of nuclear spins is important in overcoming sensitivity and resolution limitations of magnetic resonance imaging and nuclear magnetic resonance spectroscopy. Current hyperpolarisation techniques require high magnetic fields, low temperatures, or catalysts. Alternatively, the emergence of room temperature spin qubits has opened new pathways to achieve direct nuclear spin hyperpolarisation. Employing a microwave-free cross-relaxation induced polarisation protocol applied to a nitrogen vacancy qubit, we demonstrate quantum probe hyperpolarisation of external molecular nuclear spins to ~50% under ambient conditions, showing a single qubit increasing the polarisation of ~10(6) nuclear spins by six orders of magnitude over the thermal background. Results are verified against a detailed theoretical treatment, which also describes how the system can be scaled up to a universal quantum hyperpolarisation platform for macroscopic samples. Our results demonstrate the prospects for this approach to nuclear spin hyperpolarisation for molecular imaging and spectroscopy and its potential to extend beyond into other scientific areas. Nature Publishing Group UK 2018-03-28 /pmc/articles/PMC5871805/ /pubmed/29593304 http://dx.doi.org/10.1038/s41467-018-03578-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Broadway, David A.
Tetienne, Jean-Philippe
Stacey, Alastair
Wood, James D. A.
Simpson, David A.
Hall, Liam T.
Hollenberg, Lloyd C. L.
Quantum probe hyperpolarisation of molecular nuclear spins
title Quantum probe hyperpolarisation of molecular nuclear spins
title_full Quantum probe hyperpolarisation of molecular nuclear spins
title_fullStr Quantum probe hyperpolarisation of molecular nuclear spins
title_full_unstemmed Quantum probe hyperpolarisation of molecular nuclear spins
title_short Quantum probe hyperpolarisation of molecular nuclear spins
title_sort quantum probe hyperpolarisation of molecular nuclear spins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871805/
https://www.ncbi.nlm.nih.gov/pubmed/29593304
http://dx.doi.org/10.1038/s41467-018-03578-1
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