Resolving the phylogenetic origin of glioblastoma via multifocal genomic analysis of pre-treatment and treatment-resistant autopsy specimens

Glioblastomas are malignant neoplasms composed of diverse cell populations. This intratumoral diversity has an underlying architecture, with a hierarchical relationship through clonal evolution from a common ancestor. Therapies are limited by emergence of resistant subclones from this phylogenetic r...

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Detalles Bibliográficos
Autores principales: Brastianos, Priscilla K., Nayyar, Naema, Rosebrock, Daniel, Leshchiner, Ignaty, Gill, Corey M., Livitz, Dimitri, Bertalan, Mia S., D’Andrea, Megan, Hoang, Kaitlin, Aquilanti, Elisa, Chukwueke, Ugonma N., Kaneb, Andrew, Chi, Andrew, Plotkin, Scott, Gerstner, Elizabeth R., Frosch, Mathew P., Suva, Mario L., Cahill, Daniel P., Getz, Gad, Batchelor, Tracy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871833/
https://www.ncbi.nlm.nih.gov/pubmed/29872714
http://dx.doi.org/10.1038/s41698-017-0035-9

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