Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event

Improved molecular understanding is needed for rational treatment of diffuse intrinsic pontine gliomas (DIPG). Here, using multi-focal paired tumor and germline exome DNA and RNA sequencing, we uncovered phosphatase and tensin homolog (PTEN) loss as a clonal mutation in the case of a 6-year-old boy...

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Detalles Bibliográficos
Autores principales: Koschmann, Carl, Farooqui, Zishaan, Kasaian, Katayoon, Cao, Xuhong, Zamler, Daniel, Stallard, Stefanie, Venneti, Sriram, Hervey-Jumper, Shawn, Garton, Hugh, Muraszko, Karin, Franchi, Luigi, Robertson, Patricia L., Leonard, Marcia, Opipari, Valerie, Castro, Maria G., Lowenstein, Pedro R., Chinnaiyan, Arul, Mody, Rajen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871904/
https://www.ncbi.nlm.nih.gov/pubmed/29872713
http://dx.doi.org/10.1038/s41698-017-0033-y

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