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Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications

Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the tuning of their properties should be the focus of study to optimise their potential. Hydrogels have been generally limited to the delivery of h...

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Autores principales: Larrañeta, Eneko, Stewart, Sarah, Ervine, Michael, Al-Kasasbeh, Rehan, Donnelly, Ryan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872099/
https://www.ncbi.nlm.nih.gov/pubmed/29364833
http://dx.doi.org/10.3390/jfb9010013
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author Larrañeta, Eneko
Stewart, Sarah
Ervine, Michael
Al-Kasasbeh, Rehan
Donnelly, Ryan F.
author_facet Larrañeta, Eneko
Stewart, Sarah
Ervine, Michael
Al-Kasasbeh, Rehan
Donnelly, Ryan F.
author_sort Larrañeta, Eneko
collection PubMed
description Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the tuning of their properties should be the focus of study to optimise their potential. Hydrogels have been generally limited to the delivery of hydrophilic drugs. However, as many of the new drugs coming to market are hydrophobic in nature, new approaches for integrating hydrophobic drugs into hydrogels should be developed. This article discusses the possible new ways to incorporate hydrophobic drugs within hydrogel structures that have been developed through research. This review describes hydrogel-based systems for hydrophobic compound delivery included in the literature. The section covers all the main types of hydrogels, including physical hydrogels and chemical hydrogels. Additionally, reported applications of these hydrogels are described in the subsequent sections.
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spelling pubmed-58720992018-03-30 Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications Larrañeta, Eneko Stewart, Sarah Ervine, Michael Al-Kasasbeh, Rehan Donnelly, Ryan F. J Funct Biomater Review Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the tuning of their properties should be the focus of study to optimise their potential. Hydrogels have been generally limited to the delivery of hydrophilic drugs. However, as many of the new drugs coming to market are hydrophobic in nature, new approaches for integrating hydrophobic drugs into hydrogels should be developed. This article discusses the possible new ways to incorporate hydrophobic drugs within hydrogel structures that have been developed through research. This review describes hydrogel-based systems for hydrophobic compound delivery included in the literature. The section covers all the main types of hydrogels, including physical hydrogels and chemical hydrogels. Additionally, reported applications of these hydrogels are described in the subsequent sections. MDPI 2018-01-24 /pmc/articles/PMC5872099/ /pubmed/29364833 http://dx.doi.org/10.3390/jfb9010013 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Larrañeta, Eneko
Stewart, Sarah
Ervine, Michael
Al-Kasasbeh, Rehan
Donnelly, Ryan F.
Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title_full Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title_fullStr Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title_full_unstemmed Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title_short Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications
title_sort hydrogels for hydrophobic drug delivery. classification, synthesis and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872099/
https://www.ncbi.nlm.nih.gov/pubmed/29364833
http://dx.doi.org/10.3390/jfb9010013
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