Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential polyamines have many functions, but are primarily...

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Detalles Bibliográficos
Autores principales: LoGiudice, Nicole, Le, Linh, Abuan, Irene, Leizorek, Yvette, Roberts, Sigrid C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872169/
https://www.ncbi.nlm.nih.gov/pubmed/29419804
http://dx.doi.org/10.3390/medsci6010012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872169/
https://www.ncbi.nlm.nih.gov/pubmed/29419804
http://dx.doi.org/10.3390/medsci6010012

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