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Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases

The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential polyamines have many functions, but are primarily...

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Detalles Bibliográficos
Autores principales:	LoGiudice, Nicole, Le, Linh, Abuan, Irene, Leizorek, Yvette, Roberts, Sigrid C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872169/ https://www.ncbi.nlm.nih.gov/pubmed/29419804 http://dx.doi.org/10.3390/medsci6010012

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