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Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and s...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872174/ https://www.ncbi.nlm.nih.gov/pubmed/29462878 http://dx.doi.org/10.3390/medsci6010017 |
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author | Wang, Tom Kai Ming Dugo, Clementina Whalley, Gillian Wynne, Yvonne Semple, Heather Smith, Kevin Cleave, Peter Christiansen, Jonathan To, Andrew Amir, Nezar Scott, Tony Boswell, Ross Gladding, Patrick |
author_facet | Wang, Tom Kai Ming Dugo, Clementina Whalley, Gillian Wynne, Yvonne Semple, Heather Smith, Kevin Cleave, Peter Christiansen, Jonathan To, Andrew Amir, Nezar Scott, Tony Boswell, Ross Gladding, Patrick |
author_sort | Wang, Tom Kai Ming |
collection | PubMed |
description | The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH(Echo)) and left atrial enlargement (LAE(Echo)) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH(Echo) were 0.84 (0.72–0.92), 0.84 (0.73–0.92), 0.75 (0.63–0.85) and 0.62 (0.49–0.74); for LAE(Echo) 0.74 (0.6–0.85), 0.78 (0.66–0.88), 0.55 (0.42–0.67) and 0.68 (0.62–0.85); and composite SHD 0.79 (0.66–0.88), 0.87 (0.75–0.94), 0.62 (0.49–0.73) and 0.74 (0.62–0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications. |
format | Online Article Text |
id | pubmed-5872174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58721742018-03-30 Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease Wang, Tom Kai Ming Dugo, Clementina Whalley, Gillian Wynne, Yvonne Semple, Heather Smith, Kevin Cleave, Peter Christiansen, Jonathan To, Andrew Amir, Nezar Scott, Tony Boswell, Ross Gladding, Patrick Med Sci (Basel) Article The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH(Echo)) and left atrial enlargement (LAE(Echo)) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH(Echo) were 0.84 (0.72–0.92), 0.84 (0.73–0.92), 0.75 (0.63–0.85) and 0.62 (0.49–0.74); for LAE(Echo) 0.74 (0.6–0.85), 0.78 (0.66–0.88), 0.55 (0.42–0.67) and 0.68 (0.62–0.85); and composite SHD 0.79 (0.66–0.88), 0.87 (0.75–0.94), 0.62 (0.49–0.73) and 0.74 (0.62–0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications. MDPI 2018-02-15 /pmc/articles/PMC5872174/ /pubmed/29462878 http://dx.doi.org/10.3390/medsci6010017 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Tom Kai Ming Dugo, Clementina Whalley, Gillian Wynne, Yvonne Semple, Heather Smith, Kevin Cleave, Peter Christiansen, Jonathan To, Andrew Amir, Nezar Scott, Tony Boswell, Ross Gladding, Patrick Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title | Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title_full | Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title_fullStr | Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title_full_unstemmed | Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title_short | Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease |
title_sort | diagnostic utility of high sensitivity troponins for echocardiographic markers of structural heart disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872174/ https://www.ncbi.nlm.nih.gov/pubmed/29462878 http://dx.doi.org/10.3390/medsci6010017 |
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