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Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease

The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and s...

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Autores principales: Wang, Tom Kai Ming, Dugo, Clementina, Whalley, Gillian, Wynne, Yvonne, Semple, Heather, Smith, Kevin, Cleave, Peter, Christiansen, Jonathan, To, Andrew, Amir, Nezar, Scott, Tony, Boswell, Ross, Gladding, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872174/
https://www.ncbi.nlm.nih.gov/pubmed/29462878
http://dx.doi.org/10.3390/medsci6010017
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author Wang, Tom Kai Ming
Dugo, Clementina
Whalley, Gillian
Wynne, Yvonne
Semple, Heather
Smith, Kevin
Cleave, Peter
Christiansen, Jonathan
To, Andrew
Amir, Nezar
Scott, Tony
Boswell, Ross
Gladding, Patrick
author_facet Wang, Tom Kai Ming
Dugo, Clementina
Whalley, Gillian
Wynne, Yvonne
Semple, Heather
Smith, Kevin
Cleave, Peter
Christiansen, Jonathan
To, Andrew
Amir, Nezar
Scott, Tony
Boswell, Ross
Gladding, Patrick
author_sort Wang, Tom Kai Ming
collection PubMed
description The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH(Echo)) and left atrial enlargement (LAE(Echo)) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH(Echo) were 0.84 (0.72–0.92), 0.84 (0.73–0.92), 0.75 (0.63–0.85) and 0.62 (0.49–0.74); for LAE(Echo) 0.74 (0.6–0.85), 0.78 (0.66–0.88), 0.55 (0.42–0.67) and 0.68 (0.62–0.85); and composite SHD 0.79 (0.66–0.88), 0.87 (0.75–0.94), 0.62 (0.49–0.73) and 0.74 (0.62–0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications.
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spelling pubmed-58721742018-03-30 Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease Wang, Tom Kai Ming Dugo, Clementina Whalley, Gillian Wynne, Yvonne Semple, Heather Smith, Kevin Cleave, Peter Christiansen, Jonathan To, Andrew Amir, Nezar Scott, Tony Boswell, Ross Gladding, Patrick Med Sci (Basel) Article The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic markers of left ventricular hypertrophy (LVH) and structural heart disease (SHD). Patients undergoing computer gomography (CT) coronary angiogram for low-intermediate risk chest pain and healthy volunteers were recruited. Hs-troponins Singulex I, Abbott I and Roche T and N-terminal pro-brain natriuretic peptide (NT-proBNP) were evaluated in relation to SHD parameters including left ventricular hypertrophy (LVH(Echo)) and left atrial enlargement (LAE(Echo)) on echocardiography. 78 subjects who underwent echocardiography were included in this study. C-statistics (95% confidence interval) of the four biomarkers for predicting LVH(Echo) were 0.84 (0.72–0.92), 0.84 (0.73–0.92), 0.75 (0.63–0.85) and 0.62 (0.49–0.74); for LAE(Echo) 0.74 (0.6–0.85), 0.78 (0.66–0.88), 0.55 (0.42–0.67) and 0.68 (0.62–0.85); and composite SHD 0.79 (0.66–0.88), 0.87 (0.75–0.94), 0.62 (0.49–0.73) and 0.74 (0.62–0.84) respectively. Optimal cut points for SHD were >1.2 ng/L, >1.6 ng/L, >8 ng/L and >18 pmol/L respectively. These results advocate the potential role of hs-troponins as screening tools for structural heart disease with theranostic implications. MDPI 2018-02-15 /pmc/articles/PMC5872174/ /pubmed/29462878 http://dx.doi.org/10.3390/medsci6010017 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Tom Kai Ming
Dugo, Clementina
Whalley, Gillian
Wynne, Yvonne
Semple, Heather
Smith, Kevin
Cleave, Peter
Christiansen, Jonathan
To, Andrew
Amir, Nezar
Scott, Tony
Boswell, Ross
Gladding, Patrick
Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title_full Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title_fullStr Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title_full_unstemmed Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title_short Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease
title_sort diagnostic utility of high sensitivity troponins for echocardiographic markers of structural heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872174/
https://www.ncbi.nlm.nih.gov/pubmed/29462878
http://dx.doi.org/10.3390/medsci6010017
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