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Experimental In Vivo Models of Candidiasis

Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus Candida. Candida infections are among the most common human mycoses. Candida species are the third to fourth most common isolates from bloodstream infe...

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Autores principales: Segal, Esther, Frenkel, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872324/
https://www.ncbi.nlm.nih.gov/pubmed/29415485
http://dx.doi.org/10.3390/jof4010021
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author Segal, Esther
Frenkel, Michael
author_facet Segal, Esther
Frenkel, Michael
author_sort Segal, Esther
collection PubMed
description Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus Candida. Candida infections are among the most common human mycoses. Candida species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. The mucosal-cutaneous forms—particularly vaginal infections—have a high prevalence. Vaginitis caused by Candida species is the second most common vaginal infection. Hence, candidiasis is a major subject for research, including experimental in vivo models to study pathogenesis, prevention, or therapy of the disease. The following review article will focus on various experimental in vivo models in different laboratory animals, such as mammals (mice, rats, rabbits), the fruit fly–Drosophila melanogaster, the larvae of the moth Galleria mellonella, or the free-living nematode Caenorhabditis elegans. The review will describe the induction of the different clinical forms of candidiasis in the various models and the validity of such models in mimicking the human clinical situations. The use of such models for the assessment of antifungal drugs, evaluation of potential vaccines to protect before candidiasis, exploration of Candida virulence factors, and comparison of pathogenicity of different Candida species will be included in the review. All of the above will be reported as based on published studies of numerous investigators as well as on the research of the author and his group.
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spelling pubmed-58723242018-03-30 Experimental In Vivo Models of Candidiasis Segal, Esther Frenkel, Michael J Fungi (Basel) Review Candidiasis is a multifaceted fungal disease including mucosal-cutaneous, visceral, and disseminated infections caused by yeast species of the genus Candida. Candida infections are among the most common human mycoses. Candida species are the third to fourth most common isolates from bloodstream infections in neutropenic or immunocompromised hospitalized patients. The mucosal-cutaneous forms—particularly vaginal infections—have a high prevalence. Vaginitis caused by Candida species is the second most common vaginal infection. Hence, candidiasis is a major subject for research, including experimental in vivo models to study pathogenesis, prevention, or therapy of the disease. The following review article will focus on various experimental in vivo models in different laboratory animals, such as mammals (mice, rats, rabbits), the fruit fly–Drosophila melanogaster, the larvae of the moth Galleria mellonella, or the free-living nematode Caenorhabditis elegans. The review will describe the induction of the different clinical forms of candidiasis in the various models and the validity of such models in mimicking the human clinical situations. The use of such models for the assessment of antifungal drugs, evaluation of potential vaccines to protect before candidiasis, exploration of Candida virulence factors, and comparison of pathogenicity of different Candida species will be included in the review. All of the above will be reported as based on published studies of numerous investigators as well as on the research of the author and his group. MDPI 2018-02-06 /pmc/articles/PMC5872324/ /pubmed/29415485 http://dx.doi.org/10.3390/jof4010021 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Segal, Esther
Frenkel, Michael
Experimental In Vivo Models of Candidiasis
title Experimental In Vivo Models of Candidiasis
title_full Experimental In Vivo Models of Candidiasis
title_fullStr Experimental In Vivo Models of Candidiasis
title_full_unstemmed Experimental In Vivo Models of Candidiasis
title_short Experimental In Vivo Models of Candidiasis
title_sort experimental in vivo models of candidiasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872324/
https://www.ncbi.nlm.nih.gov/pubmed/29415485
http://dx.doi.org/10.3390/jof4010021
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