Cargando…

The Burden of Fungal Diseases in Romania

Objective: To estimate for the first time the burden of fungal infections in Romania. Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations, and published annual reports on local epidemiol...

Descripción completa

Detalles Bibliográficos
Autores principales: Mareș, Mihai, Moroti-Constantinescu, Valentina Ruxandra, Denning, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872334/
https://www.ncbi.nlm.nih.gov/pubmed/29494484
http://dx.doi.org/10.3390/jof4010031
_version_ 1783309814942662656
author Mareș, Mihai
Moroti-Constantinescu, Valentina Ruxandra
Denning, David W.
author_facet Mareș, Mihai
Moroti-Constantinescu, Valentina Ruxandra
Denning, David W.
author_sort Mareș, Mihai
collection PubMed
description Objective: To estimate for the first time the burden of fungal infections in Romania. Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations, and published annual reports on local epidemiology were used in the present study. When no data were available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016. Results: The estimated number of serious fungal infections in Romanian population was 436,230 in 2016. Recurrent vulvovaginal candidiasis accounted for up to 80% of total cases (more than 350,000 women annually). Concerning HIV-related infections, among 14,349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis was rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may have been as high as 1229 and 3066, respectively. In immunocompromised and cancer patient populations, the annual incidence of candidaemia was 295, and at least 458 invasive aspergillosis cases and 4 mucormycosis cases occurred yearly. With 4966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis was 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.23% of Romanians suffer from a serious form of fungal disease.
format Online
Article
Text
id pubmed-5872334
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58723342018-03-30 The Burden of Fungal Diseases in Romania Mareș, Mihai Moroti-Constantinescu, Valentina Ruxandra Denning, David W. J Fungi (Basel) Article Objective: To estimate for the first time the burden of fungal infections in Romania. Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations, and published annual reports on local epidemiology were used in the present study. When no data were available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016. Results: The estimated number of serious fungal infections in Romanian population was 436,230 in 2016. Recurrent vulvovaginal candidiasis accounted for up to 80% of total cases (more than 350,000 women annually). Concerning HIV-related infections, among 14,349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis was rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may have been as high as 1229 and 3066, respectively. In immunocompromised and cancer patient populations, the annual incidence of candidaemia was 295, and at least 458 invasive aspergillosis cases and 4 mucormycosis cases occurred yearly. With 4966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis was 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.23% of Romanians suffer from a serious form of fungal disease. MDPI 2018-03-01 /pmc/articles/PMC5872334/ /pubmed/29494484 http://dx.doi.org/10.3390/jof4010031 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mareș, Mihai
Moroti-Constantinescu, Valentina Ruxandra
Denning, David W.
The Burden of Fungal Diseases in Romania
title The Burden of Fungal Diseases in Romania
title_full The Burden of Fungal Diseases in Romania
title_fullStr The Burden of Fungal Diseases in Romania
title_full_unstemmed The Burden of Fungal Diseases in Romania
title_short The Burden of Fungal Diseases in Romania
title_sort burden of fungal diseases in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872334/
https://www.ncbi.nlm.nih.gov/pubmed/29494484
http://dx.doi.org/10.3390/jof4010031
work_keys_str_mv AT maresmihai theburdenoffungaldiseasesinromania
AT moroticonstantinescuvalentinaruxandra theburdenoffungaldiseasesinromania
AT denningdavidw theburdenoffungaldiseasesinromania
AT maresmihai burdenoffungaldiseasesinromania
AT moroticonstantinescuvalentinaruxandra burdenoffungaldiseasesinromania
AT denningdavidw burdenoffungaldiseasesinromania