Cargando…
Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analys...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872335/ https://www.ncbi.nlm.nih.gov/pubmed/29494502 http://dx.doi.org/10.3390/jof4010032 |
_version_ | 1783309815174397952 |
---|---|
author | Escandón, Patricia Lizarazo, Jairo Agudelo, Clara Inés Castañeda, Elizabeth |
author_facet | Escandón, Patricia Lizarazo, Jairo Agudelo, Clara Inés Castañeda, Elizabeth |
author_sort | Escandón, Patricia |
collection | PubMed |
description | The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26–40 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes. |
format | Online Article Text |
id | pubmed-5872335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58723352018-03-30 Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance Escandón, Patricia Lizarazo, Jairo Agudelo, Clara Inés Castañeda, Elizabeth J Fungi (Basel) Article The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26–40 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes. MDPI 2018-03-01 /pmc/articles/PMC5872335/ /pubmed/29494502 http://dx.doi.org/10.3390/jof4010032 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Escandón, Patricia Lizarazo, Jairo Agudelo, Clara Inés Castañeda, Elizabeth Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title | Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title_full | Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title_fullStr | Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title_full_unstemmed | Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title_short | Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance |
title_sort | cryptococcosis in colombia: compilation and analysis of data from laboratory-based surveillance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872335/ https://www.ncbi.nlm.nih.gov/pubmed/29494502 http://dx.doi.org/10.3390/jof4010032 |
work_keys_str_mv | AT escandonpatricia cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance AT lizarazojairo cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance AT agudeloclaraines cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance AT castanedaelizabeth cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance |