Cargando…

Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance

The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analys...

Descripción completa

Detalles Bibliográficos
Autores principales: Escandón, Patricia, Lizarazo, Jairo, Agudelo, Clara Inés, Castañeda, Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872335/
https://www.ncbi.nlm.nih.gov/pubmed/29494502
http://dx.doi.org/10.3390/jof4010032
_version_ 1783309815174397952
author Escandón, Patricia
Lizarazo, Jairo
Agudelo, Clara Inés
Castañeda, Elizabeth
author_facet Escandón, Patricia
Lizarazo, Jairo
Agudelo, Clara Inés
Castañeda, Elizabeth
author_sort Escandón, Patricia
collection PubMed
description The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26–40 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes.
format Online
Article
Text
id pubmed-5872335
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58723352018-03-30 Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance Escandón, Patricia Lizarazo, Jairo Agudelo, Clara Inés Castañeda, Elizabeth J Fungi (Basel) Article The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997–2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population. Cryptococcosis was most common in male young adults (26–40 years), with a male:female ratio of 3.9:1 in the general population and 5.4:1 in Human Immunodeficiency Virus (HIV) patients. Culture was the most common form of diagnosis in 96.3% of cases, recovering C. neoformans species in 87.5% and C. gattii in 3.1% of samples. VNI was the most prevalent (96.1%) molecular type, while VGII predominated in C. gattii isolates (54.3%). Early mortality was reported as the outcome in 47.5% of patients. Cryptococcosis remains an important opportunistic disease in Colombia and is gaining status as a primary pathogen in apparently immunocompetent patients. Our findings show the importance of including cryptococcosis as a notifiable disease, which will allow for improving opportune diagnosis and treatment, resulting in better patient outcomes. MDPI 2018-03-01 /pmc/articles/PMC5872335/ /pubmed/29494502 http://dx.doi.org/10.3390/jof4010032 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Escandón, Patricia
Lizarazo, Jairo
Agudelo, Clara Inés
Castañeda, Elizabeth
Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title_full Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title_fullStr Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title_full_unstemmed Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title_short Cryptococcosis in Colombia: Compilation and Analysis of Data from Laboratory-Based Surveillance
title_sort cryptococcosis in colombia: compilation and analysis of data from laboratory-based surveillance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872335/
https://www.ncbi.nlm.nih.gov/pubmed/29494502
http://dx.doi.org/10.3390/jof4010032
work_keys_str_mv AT escandonpatricia cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance
AT lizarazojairo cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance
AT agudeloclaraines cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance
AT castanedaelizabeth cryptococcosisincolombiacompilationandanalysisofdatafromlaboratorybasedsurveillance