Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discu...

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Detalles Bibliográficos
Autores principales: Lipovsky, Catherine E., Brumback, Brittany D., Khandekar, Aditi, Rentschler, Stacey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872364/
https://www.ncbi.nlm.nih.gov/pubmed/29517992
http://dx.doi.org/10.3390/jcdd5010016
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author Lipovsky, Catherine E.
Brumback, Brittany D.
Khandekar, Aditi
Rentschler, Stacey L.
author_facet Lipovsky, Catherine E.
Brumback, Brittany D.
Khandekar, Aditi
Rentschler, Stacey L.
author_sort Lipovsky, Catherine E.
collection PubMed
description The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity.
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spelling pubmed-58723642018-03-30 Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease Lipovsky, Catherine E. Brumback, Brittany D. Khandekar, Aditi Rentschler, Stacey L. J Cardiovasc Dev Dis Review The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity. MDPI 2018-03-08 /pmc/articles/PMC5872364/ /pubmed/29517992 http://dx.doi.org/10.3390/jcdd5010016 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lipovsky, Catherine E.
Brumback, Brittany D.
Khandekar, Aditi
Rentschler, Stacey L.
Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_full Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_fullStr Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_full_unstemmed Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_short Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease
title_sort multi-scale assessments of cardiac electrophysiology reveal regional heterogeneity in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872364/
https://www.ncbi.nlm.nih.gov/pubmed/29517992
http://dx.doi.org/10.3390/jcdd5010016
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