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Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

BACKGROUND: Oxidative stress is one of the causative factors in the pathogenesis of neuro-degenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. OBJECTIVE: We assess the effec...

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Autores principales: Nishimaki, Kiyomi, Asada, Takashi, Ohsawa, Ikuroh, Nakajima, Etsuko, Ikejima, Chiaki, Yokota, Takashi, Kamimura, Naomi, Ohta, Shigeo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872374/
https://www.ncbi.nlm.nih.gov/pubmed/29110615
http://dx.doi.org/10.2174/1567205014666171106145017
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author Nishimaki, Kiyomi
Asada, Takashi
Ohsawa, Ikuroh
Nakajima, Etsuko
Ikejima, Chiaki
Yokota, Takashi
Kamimura, Naomi
Ohta, Shigeo
author_facet Nishimaki, Kiyomi
Asada, Takashi
Ohsawa, Ikuroh
Nakajima, Etsuko
Ikejima, Chiaki
Yokota, Takashi
Kamimura, Naomi
Ohta, Shigeo
author_sort Nishimaki, Kiyomi
collection PubMed
description BACKGROUND: Oxidative stress is one of the causative factors in the pathogenesis of neuro-degenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. OBJECTIVE: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. METHODS: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a ran-domized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year. RESULTS: In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was long-er than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) geno-type in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). CONCLUSION: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.
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spelling pubmed-58723742018-04-11 Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment Nishimaki, Kiyomi Asada, Takashi Ohsawa, Ikuroh Nakajima, Etsuko Ikejima, Chiaki Yokota, Takashi Kamimura, Naomi Ohta, Shigeo Curr Alzheimer Res Article BACKGROUND: Oxidative stress is one of the causative factors in the pathogenesis of neuro-degenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. OBJECTIVE: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. METHODS: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a ran-domized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year. RESULTS: In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was long-er than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) geno-type in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score). CONCLUSION: H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI. Bentham Science Publishers 2018-04 /pmc/articles/PMC5872374/ /pubmed/29110615 http://dx.doi.org/10.2174/1567205014666171106145017 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Nishimaki, Kiyomi
Asada, Takashi
Ohsawa, Ikuroh
Nakajima, Etsuko
Ikejima, Chiaki
Yokota, Takashi
Kamimura, Naomi
Ohta, Shigeo
Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title_full Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title_fullStr Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title_full_unstemmed Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title_short Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment
title_sort effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872374/
https://www.ncbi.nlm.nih.gov/pubmed/29110615
http://dx.doi.org/10.2174/1567205014666171106145017
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